School of Pharmaceutical Sciences , Guangzhou University of Chinese Medicine , Guangzhou 510006 , China.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Sun Yat-Sen University Cancer Center , Guangzhou 510060 , China.
Org Lett. 2020 Feb 21;22(4):1336-1339. doi: 10.1021/acs.orglett.9b04648. Epub 2020 Feb 10.
Aspermeroterpene A () with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B () and C (), were isolated from the marine-derived fungus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for - is proposed. Aspermeroterpenes A-C (-) showed significant inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells compared to positive control.
从海洋来源真菌 Aspergillus sp. GZU-31-1 中分离得到了一个具有前所未有的高度拥挤的 5/3/6/6/6/5 六元环骨架的新倍半萜 Aspermeroterpene A ()，以及两个前体 Aspermeroterpenes B () 和 C ()。通过量子化学计算、X 射线衍射和光谱方法确定了它们的结构。提出了 - 的生物合成途径。与阳性对照相比， Aspermeroterpenes A-C (-) 对 LPS 诱导的 RAW 264.7 细胞中一氧化氮 (NO) 的产生具有显著的抑制活性。
