Seyler L E, Pomerleau O F, Fertig J B, Hunt D, Parker K
Pharmacol Biochem Behav. 1986 Jan;24(1):159-62. doi: 10.1016/0091-3057(86)90062-6.
Nausea was induced by having subjects smoke two high nicotine cigarettes in quick succession. Plasma levels of prolactin, adrenocorticotropic hormone, beta-endorphin/beta-lipotropin, growth hormone, arginine vasopressin, and neurophysin I increased without changes in thyroid stimulating hormone, luteinizing hormone, or follicle stimulating hormone. Nausea and pituitary hormone release correlated with high nicotine intake (smoking 2.87 mg nicotine cigarettes) but did not occur during lower nicotine intake (smoking 0.48 mg nicotine cigarettes). Individual differences in nausea and related hormonal responses may provide an objective method for predicting receptivity to smoking.
通过让受试者连续快速吸两支高尼古丁香烟来诱发恶心。催乳素、促肾上腺皮质激素、β-内啡肽/β-促脂解素、生长激素、精氨酸加压素和神经垂体素I的血浆水平升高，而促甲状腺激素、黄体生成素或促卵泡激素水平无变化。恶心和垂体激素释放与高尼古丁摄入量（吸含2.87毫克尼古丁的香烟）相关，但在低尼古丁摄入量（吸含0.48毫克尼古丁的香烟）期间未出现。恶心及相关激素反应的个体差异可能为预测吸烟易感性提供一种客观方法。
