Jiang Ning, Liu Xinwei, Sui Baiyan, Wang Jiale, Liu Xin, Zhang Zun
Department of Oral and Craniomaxillofacial Science, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China.
Department of Dental Materials, Shanghai Biomaterials Research & Testing Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China.
Pharmaceutics. 2024 Sep 25;16(10):1244. doi: 10.3390/pharmaceutics16101244.
Excessive reactive oxygen species (ROS) in diabetic wounds are major contributors to chronic wounds and impaired healing, posing significant challenges in regenerative medicine. Developing innovative drug delivery systems is crucial to address these issues by modifying the adverse microenvironment and promoting effective wound healing. Herein, we designed a novel drug delivery platform using manganese dioxide nanoflower hybridized gold nanoparticle composites (MnO-Au) synthesized via a hydrothermal reaction, and investigated the potential of MnO-Au nanoflowers to relieve the high oxidative stress microenvironment and regulate diabetic wound tissue healing. This hybrid material demonstrated superior catalytic activity compared to MnO alone, enabling the rapid decomposition of hydrogen peroxide and a substantial reduction in ROS levels within dermal fibroblasts. The MnO-Au nanoflowers also facilitated enhanced dermal fibroblast migration and expression, which are critical for tissue regeneration. Additionally, a hydrogel-based wound dressing incorporating MnO-Au nanoflowers was developed, showing its potential as an intelligent drug delivery system. This dressing significantly reduced oxidative stress, accelerated wound closure, and improved the quality of neonatal epithelial tissue regeneration in a diabetic rat skin defect model. Our findings underscore the potential of MnO-Au nanoflower-based drug delivery systems as a promising therapeutic approach for chronic wound healing, particularly in regenerative medicine.
糖尿病伤口中过量的活性氧（ROS）是导致慢性伤口和愈合受损的主要因素，给再生医学带来了重大挑战。开发创新的药物递送系统对于通过改善不利的微环境和促进有效的伤口愈合来解决这些问题至关重要。在此，我们设计了一种新型药物递送平台，使用通过水热反应合成的二氧化锰纳米花杂交金纳米颗粒复合材料（MnO-Au），并研究了MnO-Au纳米花缓解高氧化应激微环境和调节糖尿病伤口组织愈合的潜力。与单独的MnO相比，这种杂化材料表现出优异的催化活性，能够快速分解过氧化氢并大幅降低真皮成纤维细胞内的ROS水平。MnO-Au纳米花还促进了真皮成纤维细胞迁移和表达的增强，这对组织再生至关重要。此外，还开发了一种包含MnO-Au纳米花的水凝胶基伤口敷料，显示出其作为智能药物递送系统的潜力。在糖尿病大鼠皮肤缺损模型中，这种敷料显著降低了氧化应激，加速了伤口闭合，并改善了新生上皮组织再生的质量。我们的研究结果强调了基于MnO-Au纳米花的药物递送系统作为慢性伤口愈合，特别是再生医学中一种有前景的治疗方法的潜力。
