Salimi Elias, Assar Shirin, Salimi Aram, Mohamadzadeh Dena
Clinical Research Development Centre, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mediterr J Rheumatol. 2024 May 21;35(3):459-463. doi: 10.31138/mjr.101223.fcd. eCollection 2024 Sep.
Systemic sclerosis (SSc) is an autoimmune disorder characterised by skin fibrosis leading to skin tightening and disfigurement. However, there is no definite treatment for SSc and its skin complications. Fractional carbon dioxide laser has been widely used for different cutaneous pathologies. This study aims to evaluate the benefits of CO2 laser resurfacing on microstomia and peri-oral rhytids in systemic sclerosis patients.
33 systemic sclerosis patients were enrolled. Four sessions of CO2 laser treatment were performed at an interval of four weeks. Patients were evaluated monthly. The interincisal distance (IID) measurement was used to evaluate maximal mouth opening capacity, and the mouth handicap in systemic sclerosis (MHISS) scale was used to assess the improvement after treatment.
All of the participants were female with a mean age of 47.46 and a standard deviation of 7.11. The mean disease duration was 12.35. The mean total core of the MHISS scale was 25.24, and the mean IID was 48.11 millimetres before the treatment with CO2 laser. The MHISS score decreased, and patient satisfaction increased after treatment. However, observed differences in the results of IID were not statistically significant.
In conclusion, it seems that the fractional carbon dioxide laser is effective in the improvement of perioral rhytids, patient satisfaction based on the MHISS score, and mouth disability in SSc patients.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为皮肤纤维化，导致皮肤紧绷和容貌毁损。然而，对于系统性硬化症及其皮肤并发症尚无确切的治疗方法。二氧化碳点阵激光已广泛应用于不同的皮肤病症。本研究旨在评估二氧化碳激光换肤术对系统性硬化症患者小口畸形和口周皱纹的疗效。
纳入33例系统性硬化症患者。每隔四周进行四次二氧化碳激光治疗。每月对患者进行评估。采用切牙间距离（IID）测量来评估最大张口能力，并用系统性硬化症口部功能障碍（MHISS）量表评估治疗后的改善情况。
所有参与者均为女性，平均年龄47.46岁，标准差7.11。平均病程为12.35年。在进行二氧化碳激光治疗前，MHISS量表的平均总分是25.24，平均IID为48.11毫米。治疗后MHISS评分降低，患者满意度提高。然而，观察到的IID结果差异无统计学意义。
总之，二氧化碳点阵激光似乎对改善系统性硬化症患者的口周皱纹、基于MHISS评分的患者满意度及口部功能障碍有效。
