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从一名患有囊性纤维化的婴儿肺部分离出的未培养噬菌体COMBAT-CF_PAR1的近乎完整的基因组。

A near-complete genome of the uncultured phage COMBAT-CF_PAR1 isolated from the lungs of an infant with cystic fibrosis.

作者信息

Agudelo-Romero Patricia, Caparros-Martin Jose A, Sharma Abhinav, Saladié Montserrat, Sly Peter D, Stick Stephen M, O Gara Fergal

机构信息

Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, Western Australia, Australia.

Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Perth, Western Australia, Australia.

出版信息

Microbiol Resour Announc. 2024 Dec 12;13(12):e0104724. doi: 10.1128/mra.01047-24. Epub 2024 Oct 29.

DOI:10.1128/mra.01047-24
PMID:39470239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11636395/
Abstract

In cystic fibrosis, bacteria-bacteriophage interaction in the lower airways is poorly understood. We present the near-complete genome of the uncultured Siphovirus-like bacteriophage, phage COMBAT-CF_PAR1, isolated from the lower airways. The genome spans 41,510 bp with 33.45% guanine-cytosine content and contains 65 open reading frames.

摘要

在囊性纤维化中,下呼吸道中细菌与噬菌体的相互作用尚不清楚。我们展示了从未培养的类丝状噬菌体(噬菌体COMBAT-CF_PAR1)的近乎完整的基因组,该噬菌体是从下呼吸道分离出来的。该基因组跨度为41,510碱基对,鸟嘌呤-胞嘧啶含量为33.45%,包含65个开放阅读框。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/11636395/fa2e868ff78e/mra.01047-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/11636395/fa2e868ff78e/mra.01047-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7781/11636395/fa2e868ff78e/mra.01047-24.f001.jpg

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Microbiome. 2023 Jun 13;11(1):132. doi: 10.1186/s40168-023-01543-9.
3
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5
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