Bardwell A, Hill D W, Runyon B A, Koster F T
Arch Intern Med. 1986 Feb;146(2):385-6.
Disseminated candidiasis usually occurs in profoundly immunocompromised hosts. We described a case of disseminated macronodular cutaneous candidiasis in a man with no known risk for immunosuppression other than alcoholic liver disease and a second case of multiple macronodular cutaneous abscesses in an alcoholic man who had no evidence of systemic dissemination. One patient had testicular candidiasis, a previously unreported site of infection in disseminated candidiasis. Tests showed neutrophil and lymphocyte function to be normal; however, a marked defect in serum opsonization was demonstrated in one patient. It is postulated that chronic alcoholism with alcoholic liver disease resulted in impaired serum opsonization, which, in turn, predisposed these patients to candidal infection.
播散性念珠菌病通常发生在免疫功能严重受损的宿主中。我们描述了一例播散性大结节性皮肤念珠菌病病例，患者为一名男性，除酒精性肝病外无其他已知的免疫抑制风险因素；还描述了另一例酒精性男性患者的多发性大结节性皮肤脓肿病例，该患者无全身播散的证据。其中一名患者患有睾丸念珠菌病，这是播散性念珠菌病中此前未报道过的感染部位。检测显示中性粒细胞和淋巴细胞功能正常；然而，一名患者的血清调理作用存在明显缺陷。据推测，慢性酒精中毒伴酒精性肝病导致血清调理作用受损，进而使这些患者易患念珠菌感染。
