Department of Urology, Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Department of Geriatric Endocrinology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
ACS Nano. 2024 Nov 12;18(45):30911-30918. doi: 10.1021/acsnano.4c07969. Epub 2024 Oct 30.
The era of molecular medicine arose as we began to diagnose and treat diseases based on understanding how genes, proteins, and cells work, providing optimal therapeutic care through molecular profiling. Central to molecular medicine is molecular recognition, which is underpinned by techniques involving omics analysis, gene editing, and targeted agents. Recent advancements in these tools not only expand our understanding of biological processes but also aid in the development of diagnostic and treatment modalities at the molecular level, thus bridging the gap between medical research and clinical applications. This perspective traces the development of molecular tools, highlighting, along the way, their pivotal role in advancing molecular medicine for the global health of people.
分子医学时代的出现，源于我们开始基于对基因、蛋白质和细胞如何工作的理解来诊断和治疗疾病，通过分子谱分析提供最佳的治疗护理。分子医学的核心是分子识别，它由涉及组学分析、基因编辑和靶向药物等技术来支撑。这些工具的最新进展不仅扩展了我们对生物过程的理解，还有助于在分子水平上开发诊断和治疗方法，从而弥合医学研究和临床应用之间的差距。本文追溯了分子工具的发展，沿途强调了它们在推进人类全球健康的分子医学方面的关键作用。
