铜驱动代谢状态重塑及透明细胞肾细胞癌进展

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

作者信息

Bischoff Megan E, Shamsaei Behrouz, Yang Juechen, Secic Dina, Vemuri Bhargav, Reisz Julie A, D'Alessandro Angelo, Bartolacci Caterina, Adamczak Rafal, Schmidt Lucas, Wang Jiang, Martines Amelia, Venkat Jahnavi, Tcheuyap Vanina Toffessi, Biesiada Jacek, Behrmann Catherine A, Vest Katherine E, Brugarolas James, Scaglioni Pier Paolo, Plas David R, Patra Krushna C, Gulati Shuchi, Landero Figueroa Julio A, Meller Jarek, Cunningham John T, Czyzyk-Krzeska Maria F

机构信息

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Cancer Discov. 2025 Feb 7;15(2):401-426. doi: 10.1158/2159-8290.CD-24-0187.

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.