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铜驱动代谢状态重塑及透明细胞肾细胞癌进展

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

作者信息

Bischoff Megan E, Shamsaei Behrouz, Yang Juechen, Secic Dina, Vemuri Bhargav, Reisz Julie A, D'Alessandro Angelo, Bartolacci Caterina, Adamczak Rafal, Schmidt Lucas, Wang Jiang, Martines Amelia, Venkat Jahnavi, Tcheuyap Vanina Toffessi, Biesiada Jacek, Behrmann Catherine A, Vest Katherine E, Brugarolas James, Scaglioni Pier Paolo, Plas David R, Patra Krushna C, Gulati Shuchi, Landero Figueroa Julio A, Meller Jarek, Cunningham John T, Czyzyk-Krzeska Maria F

机构信息

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Cancer Discov. 2025 Feb 7;15(2):401-426. doi: 10.1158/2159-8290.CD-24-0187.

DOI:10.1158/2159-8290.CD-24-0187
PMID:39476412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
Abstract

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.

摘要

这项研究确立了能量产生与氧化还原稳态之间葡萄糖依赖性协调的要求，这对于积累铜并促进肿瘤生长的癌细胞的存活至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/206f07d32185/cd-24-0187fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/0fc76c5d374e/cd-24-0187fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/a227480a6673/cd-24-0187fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/73ba120aaa3c/cd-24-0187fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/e2b93f3d3a03/cd-24-0187fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/95f940ba5818/cd-24-0187fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/206f07d32185/cd-24-0187fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/0fc76c5d374e/cd-24-0187fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/a227480a6673/cd-24-0187fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/73ba120aaa3c/cd-24-0187fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/e2b93f3d3a03/cd-24-0187fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/95f940ba5818/cd-24-0187fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg

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Mitochondrial complex I promotes kidney cancer metastasis.线粒体复合物 I 促进肾癌转移。
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Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.对透明细胞肾细胞癌进行多组学分析，确定与疾病进展相关的代谢重编程。
具有铜还原酶活性的STEAP4通过调节肝癌细胞的细胞周期来抑制肿瘤发生。
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The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes.谷胱甘肽系统：从蓝细菌到高等真核生物的历程
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A druggable copper-signalling pathway that drives inflammation.一个可药物干预的铜信号通路驱动炎症反应。
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