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铜驱动代谢状态重塑及透明细胞肾细胞癌进展

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

作者信息

Bischoff Megan E, Shamsaei Behrouz, Yang Juechen, Secic Dina, Vemuri Bhargav, Reisz Julie A, D'Alessandro Angelo, Bartolacci Caterina, Adamczak Rafal, Schmidt Lucas, Wang Jiang, Martines Amelia, Venkat Jahnavi, Tcheuyap Vanina Toffessi, Biesiada Jacek, Behrmann Catherine A, Vest Katherine E, Brugarolas James, Scaglioni Pier Paolo, Plas David R, Patra Krushna C, Gulati Shuchi, Landero Figueroa Julio A, Meller Jarek, Cunningham John T, Czyzyk-Krzeska Maria F

机构信息

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Cancer Discov. 2025 Feb 7;15(2):401-426. doi: 10.1158/2159-8290.CD-24-0187.

DOI:10.1158/2159-8290.CD-24-0187
PMID:39476412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
Abstract

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.

摘要

这项研究确立了能量产生与氧化还原稳态之间葡萄糖依赖性协调的要求，这对于积累铜并促进肿瘤生长的癌细胞的存活至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/206f07d32185/cd-24-0187fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/0fc76c5d374e/cd-24-0187fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/a227480a6673/cd-24-0187fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/73ba120aaa3c/cd-24-0187fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/e2b93f3d3a03/cd-24-0187fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/95f940ba5818/cd-24-0187fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/206f07d32185/cd-24-0187fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/0fc76c5d374e/cd-24-0187fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/a227480a6673/cd-24-0187fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/73ba120aaa3c/cd-24-0187fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/e2b93f3d3a03/cd-24-0187fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/95f940ba5818/cd-24-0187fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d454/11803400/597bae001d7b/cd-24-0187fig7.jpg

相似文献

[1]
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

Cancer Discov. 2025-2-7

[2]
Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma.

bioRxiv. 2024-1-19

[3]
Re: Multi-omic Profiling of Clear Cell Renal Cell Carcinoma Identifies Metabolic Reprogramming Associated with Disease Progression.

Eur Urol. 2024-7

[4]
CD151 expression can predict cancer progression in clear cell renal cell carcinoma.

Histopathology. 2011-1

[5]
Prognostic Significance of CD24 in Clear Cell Renal Cell Carcinoma.

Pathol Oncol Res. 2017-4

[6]
Downregulation of YAP in Clear Cell Renal Cell Carcinoma Contributes to Poor Prognosis and Progressive Features.

Ann Clin Lab Sci. 2017-1

[7]
GYS1 induces glycogen accumulation and promotes tumor progression via the NF-κB pathway in Clear Cell Renal Carcinoma.

Theranostics. 2020

[8]
Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch.

Mol Cancer Ther. 2020-7

[9]
NR1B2 suppress kidney renal clear cell carcinoma (KIRC) progression by regulation of LATS 1/2-YAP signaling.

J Exp Clin Cancer Res. 2019-8-7

[10]
Metabolic reprogramming in renal cancer: Events of a metabolic disease.

Biochim Biophys Acta Rev Cancer. 2021-8

引用本文的文献

[1]
Blood and Serum Copper and Zinc Levels and 10-Year Survival of Patients After Kidney Cancer Diagnosis.

Nutrients. 2025-3-8

[2]
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data.

Mol Cell Proteomics. 2025-7

[3]
STEAP4 with copper reductase activity suppresses tumorigenesis by regulating the cell cycle in hepatocellular carcinoma cells.

Cell Div. 2024-12-24

本文引用的文献

[1]
Mitochondrial membrane lipids in the regulation of bioenergetic flux.

Cell Metab. 2024-9-3

[2]
Mitochondrial complex I promotes kidney cancer metastasis.

Nature. 2024-9

[3]
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.

Nat Genet. 2024-3

[4]
Manipulating mitochondrial electron flow enhances tumor immunogenicity.

Science. 2023-9-22

[5]
The Glutathione System: A Journey from Cyanobacteria to Higher Eukaryotes.

Antioxidants (Basel). 2023-5-31

[6]
A druggable copper-signalling pathway that drives inflammation.

Nature. 2023-5

[7]
Copper-dependent autophagic degradation of GPX4 drives ferroptosis.

Autophagy. 2023-7

[8]
Regulation of Mitochondrial Hydrogen Peroxide Availability by Protein S-glutathionylation.

Cells. 2022-12-27

[9]
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer.

Cancer Cell. 2022-12-12

[10]
Cardiolipin Regulates Mitochondrial Ultrastructure and Function in Mammalian Cells.

Genes (Basel). 2022-10-18

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