Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, L3 5QA Liverpool, U.K.
Department of Civil Engineering, University of British Columbia, 2002-6250 Applied Science Lane, Vancouver, British Columbia V6T 1Z4, Canada.
Environ Sci Technol. 2024 Nov 12;58(45):19981-19989. doi: 10.1021/acs.est.4c09821. Epub 2024 Oct 31.
Disinfection efficacy tests were conducted on surface carriers inoculated with the monkeypox virus (MPXV) by applying six disinfectant solutions (and three controls) on six surfaces common in low-resource settings: four nonporous surfaces (stainless steel, glass, plastic, and latex) and two porous surfaces (ceramic and wood). Disinfectants were wiped on carriers in triplicate, with a 1 min contact time: 0.05 and 0.5% sodium hypochlorite, 70% ethanol, two quaternary ammonium compound (QAC)-based disinfectants, and 1.4% hydrogen peroxide. MPXV was then quantified, and log removal values were calculated. Sodium hypochlorite (0.05 and 0.5%) and ethanol (70%) removed MPXV to below detection level, ≥ 99.97% reduction for nonporous surfaces, and ≥99.40% for wood, QAC-based disinfectants were efficacious on nonporous surfaces (≥99.97% inactivation) but had diminished efficacy on wood, a porous surface, and 1.4% HO had limited efficacy across all tested surfaces. Results varied by disinfectant type and surface type. Based on our results, we recommend using 0.05% sodium hypochlorite or 70% ethanol with 1 min contact time to inactive MPXV on clean nonporous and porous surfaces. As MPXV is evolving, future research with additional disinfectants, application methods, and environmental conditions and research to understand adsorption, disinfection efficacy, and transmission risk on porous surfaces are needed to develop practical disinfection recommendations.
对表面载体进行了消毒功效测试，这些载体接种了猴痘病毒（MPXV），使用六种消毒剂（和三种对照剂）对六种在低资源环境中常见的表面进行了处理：四种非多孔表面（不锈钢、玻璃、塑料和乳胶）和两种多孔表面（陶瓷和木材）。消毒剂在载体上擦拭了三遍，接触时间为 1 分钟：0.05%和 0.5%次氯酸钠、70%乙醇、两种季铵化合物（QAC）基消毒剂和 1.4%过氧化氢。然后对 MPXV 进行了定量，并计算了对数去除值。次氯酸钠（0.05%和 0.5%）和乙醇（70%）将 MPXV 去除至检测不到的水平，非多孔表面的减少率≥99.97%，木材的减少率≥99.40%，QAC 基消毒剂对非多孔表面有效（≥99.97%失活），但对多孔表面木材的效果减弱，1.4%HO 在所有测试表面的效果有限。结果因消毒剂类型和表面类型而异。根据我们的结果，我们建议使用 0.05%次氯酸钠或 70%乙醇，接触时间为 1 分钟，以在清洁的非多孔和多孔表面上使 MPXV 失活。随着 MPXV 的不断演变，需要进行更多的消毒剂、应用方法和环境条件的研究，并进行对多孔表面吸附、消毒效果和传播风险的研究，以制定实际的消毒建议。
