Wang Yabing, Fan Zhenling, Ren Jianli, Ma Lin
Department of Obstetrical, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei Province, People's Republic of China.
Department of Hemodialysis, Handan Mingren Hospital, Handan, Hebei Province, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Oct 29;17:4003-4012. doi: 10.2147/DMSO.S475385. eCollection 2024.
To explore the relationship between changes in oxidative stress markers in pregnant women of advanced maternal age with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes and neonatal neurodevelopment, as well as their predictive value.
Two hundred pregnant women of advanced maternal age were selected and divided into Group A (normal blood sugar) and Group B (GDM) based on the 75 g (Oral Glucose Tolerance Test) OGTT results. Oxidative stress markers were measured, and pregnancy outcomes and neonatal Neonatal Behavioral Assessment Scale (NABA) scores were recorded.
Malondialdehyde (MDA) levels in Group B were higher than those in Group A, while Glutathione (GSH) and Superoxide Dismutase (SOD) levels were lower. Group B had higher rates of adverse pregnancy outcomes and neurological abnormalities than Group A. The Area Under the Curve (AUC) values for serum MDA, GSH, and SOD levels combined prediction were higher than those for individual predictions (P<0.05).
Oxidative stress markers in pregnant women of advanced maternal age with GDM are associated with adverse pregnancy outcomes and neonatal abnormalities, and combined prediction has good predictive efficiency (AUC>0.7).
探讨高龄妊娠合并妊娠期糖尿病（GDM）孕妇氧化应激标志物变化与不良妊娠结局及新生儿神经发育的关系及其预测价值。
选取200例高龄孕妇，根据75g口服葡萄糖耐量试验（OGTT）结果分为A组（血糖正常）和B组（GDM）。检测氧化应激标志物，记录妊娠结局及新生儿神经行为评定量表（NABA）评分。
B组丙二醛（MDA）水平高于A组，而谷胱甘肽（GSH）和超氧化物歧化酶（SOD）水平低于A组。B组不良妊娠结局及神经异常发生率高于A组。血清MDA、GSH和SOD水平联合预测的曲线下面积（AUC）值高于单项预测（P<0.05）。
高龄妊娠合并GDM孕妇的氧化应激标志物与不良妊娠结局及新生儿异常有关，联合预测具有良好的预测效能（AUC>0.7）。
