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使用边缘检测技术对肌纤维畸形进行量化以研究慢性肌肉压疮。

Quantification of muscle fiber malformations using edge detection to investigate chronic muscle pressure ulcers.

作者信息

Ong Charlene Z L, Nasir N Jannah M, Welsch Roy E, Tucker-Kellogg Lisa, Rajapakse Jagath C

机构信息

Health Informatics Lab, College of Computing and Data Science, Nanyang Technological University, Singapore, Singapore.

Centre for Computational Biology and Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, Singapore.

出版信息

Front Bioinform. 2024 Oct 21;4:1450146. doi: 10.3389/fbinf.2024.1450146. eCollection 2024.

DOI:10.3389/fbinf.2024.1450146
PMID:39497739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11532102/
Abstract

BACKGROUND

Microscopy of regenerated tissue shows different morphologies between the healing of acute wounds and chronic wounds. This difference can be seen manually by biologists, but computational methods are needed to automate the characterization of morphology and regenerative quality in regenerated muscle tissue.

RESULTS

From the detected edge segments, we computed several imaging biomarkers of interest, such as median tortuosity, number of edge segments normalized by area, median edge segment distance and interquartile range of orientation angles of edge segments of the microscope images of successful and unsuccessful muscle regeneration. We observed that muscle fibers in saline-treated pressure ulcers had a larger interquartile range of orientation angles of the edge segments (p = 0.05) and shorter edge segment distances (p = 0.003) compared to those of acute cardiotoxin injuries.

CONCLUSION

Our edge detection method was able to identify statistically significant differences in some of the imaging biomarkers between saline-treated pressure ulcers and cardiotoxin injuries, suggesting that chronic pressure ulcers have increased muscle fiber malformations compared to cardiotoxin injuries.

摘要

背景

再生组织的显微镜检查显示，急性伤口和慢性伤口愈合之间存在不同的形态。生物学家可以手动观察到这种差异，但需要计算方法来自动表征再生肌肉组织的形态和再生质量。

结果

从检测到的边缘片段中，我们计算了几个感兴趣的成像生物标志物，例如成功和不成功肌肉再生的显微镜图像边缘片段的中值曲折度、按面积归一化的边缘片段数量、中值边缘片段距离和边缘片段取向角的四分位间距。我们观察到，与急性心脏毒素损伤相比，盐水处理的压疮中的肌纤维边缘片段取向角的四分位间距更大（p = 0.05），边缘片段距离更短（p = 0.003）。

结论

我们的边缘检测方法能够识别盐水处理的压疮和心脏毒素损伤之间某些成像生物标志物的统计学显著差异，这表明与心脏毒素损伤相比，慢性压疮的肌纤维畸形增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3f/11532102/dbf14c8399e9/fbinf-04-1450146-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3f/11532102/0992a0ad2026/fbinf-04-1450146-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3f/11532102/af338bf0c352/fbinf-04-1450146-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f3f/11532102/576355f73fd9/fbinf-04-1450146-g010.jpg
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Key concepts in muscle regeneration: muscle "cellular ecology" integrates a gestalt of cellular cross-talk, motility, and activity to remodel structure and restore function.肌肉再生的关键概念：肌肉“细胞生态学”整合了细胞串扰、运动和活动的整体，以重塑结构并恢复功能。
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