Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Institute of Reproduction and Development, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Front Cell Infect Microbiol. 2024 Oct 21;14:1440742. doi: 10.3389/fcimb.2024.1440742. eCollection 2024.
A growing body of research has established a correlation between tumors and persistent chronic inflammatory infiltration. As a primary instigator of inflammation, the majority of microbiomes naturally residing within our bodies engage in a mutually beneficial symbiotic relationship. Nevertheless, alterations in the microbiome's composition or breaches in the normal barrier function can disrupt the internal environment's homeostasis, potentially leading to the development and progression of various diseases, including tumors. The investigation of tumor-related microbiomes has contributed to a deeper understanding of their role in tumorigenesis. This review offers a comprehensive overview of the microbiome alterations and the associated inflammatory changes in ovarian cancer. It may aid in advancing research to elucidate the mechanisms underlying the ovarian cancer-associated microbiome, providing potential theoretical support for the future development of microbiome-targeted antitumor therapies and early screening through convenient methods.
越来越多的研究已经证实肿瘤与持续的慢性炎症浸润之间存在关联。作为炎症的主要引发者，我们体内大部分的微生物组与人体处于互利共生的关系。然而，微生物组组成的改变或正常屏障功能的破坏可能会打破内部环境的稳态，从而导致各种疾病的发生和发展，包括肿瘤。对与肿瘤相关的微生物组的研究有助于深入了解它们在肿瘤发生中的作用。这篇综述全面概述了卵巢癌中微生物组的改变及其相关的炎症变化。它可能有助于推进研究，阐明与卵巢癌相关的微生物组的机制，为未来通过方便的方法进行微生物组靶向抗肿瘤治疗和早期筛查提供潜在的理论支持。
