Chu Haidi, Wang Dong, Qu Yanqing
Department of Thyroid Surgery, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China.
Department of Thyroid Surgery, Affiliated Hospital of Qingdao University, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Oncol Lett. 2024 Nov 5;29(1):43. doi: 10.3892/ol.2024.14789. eCollection 2025 Jan.
The present study reports a rare case of skin metastasis in a 26-year-old female patient with a history of PTC positive for the mutation. During the 2.5-year follow-up period after the initial surgical treatment of PTC, no evidence of distant metastasis was found via thyroglobulin measurements, neck ultrasound, or neck and chest computed tomography. However, following this period, the patient reported two skin nodules on the left side of the neck. Ultrasound-guided punch biopsy was performed, and the pathology results demonstrated that the patient had skin metastases from the PTC. The patient received surgical resection and complete removal of nodules, and was subsequently discharged from the hospital. A literature review showed that there are numerous potential mechanisms for skin metastasis, and the treatments are diverse and dependent on the patient condition. While surgical treatment may effectively improve patient symptoms and prognosis, long-term surveillance for recurrence is recommended for high-risk cases. Skin metastasis of PTC should be suspected in patients who develop an upper body skin lesion with a history of PTC, even without evidence of disease metastasis. For high-risk patients with skin metastasis of PTC with and gene mutations, long-term surveillance for recurrence should be recommended in cases with a poor prognosis, and further research of these cases should be conducted in the future to optimize surgical and medical care.
本研究报告了一例罕见的皮肤转移病例，患者为一名26岁女性，有PTC病史且 突变呈阳性。在PTC初次手术治疗后的2.5年随访期内，通过甲状腺球蛋白测量、颈部超声或颈部及胸部计算机断层扫描未发现远处转移迹象。然而，在此之后，患者报告颈部左侧出现两个皮肤结节。进行了超声引导下的穿刺活检，病理结果显示患者发生了PTC皮肤转移。患者接受了手术切除并完全切除结节，随后出院。文献综述表明，皮肤转移有多种潜在机制，治疗方法多样且取决于患者情况。虽然手术治疗可能有效改善患者症状和预后，但对于高危病例，建议进行长期复发监测。有PTC病史的患者若出现上身皮肤病变，即使没有疾病转移证据，也应怀疑PTC皮肤转移。对于有 和 基因突变的PTC皮肤转移高危患者，预后不良的病例应建议进行长期复发监测，未来应对这些病例进行进一步研究以优化手术和医疗护理。
