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合成代谢类固醇使用与高血压和心肌病的关联:一项病例研究。

Association of Anabolic Steroid Use With Hypertension and Cardiomyopathy: A Case Study.

作者信息

Neupane Sarvesh, Kalra Falguni

机构信息

Internal Medicine, Touro College of Osteopathic Medicine/Montefiore Nyack Hospital, Nyack, USA.

Internal Medicine, Sound Physicians/Montefiore Nyack Hospital, Nyack, USA.

出版信息

Cureus. 2024 Oct 18;16(10):e71775. doi: 10.7759/cureus.71775. eCollection 2024 Oct.

Abstract

Anabolic-androgenic steroid (AAS) use has always been associated with professional athletes and bodybuilders. Many scandals have shed light on the power of anabolic steroids in enhancing human physique and performance, making them ripe for abuse amongst recreational users. However, there are many dangers of anabolic steroid use that have yet to be uncovered or are slowly making their way into becoming general knowledge, especially as it relates to cardiovascular disease (CVD). These risks may remain masked for years before they are discovered, by which time it may be too late to reverse all the detrimental effects. In this article, we report a case of an otherwise healthy 46-year-old Caucasian male with an admitted history of recent anabolic steroid use who arrived in the emergency department with complaints of left lower extremity swelling and pain, spontaneous bruising of the calf, and shortness of breath for two days. After a thorough evaluation, he was discovered to have underlying essential hypertension (HTN) and heart failure with a reduced ejection fraction of 30%. The patient was educated on the likely effects of steroid use on his condition and the ramifications of having uncontrolled HTN and heart failure. He was advised to discontinue steroid use and begin medical management of these conditions. Ultimately, there isn't an established symptom profile for patients using anabolic steroids, and this unique case of a patient with vague symptomatology who was discovered to have underlying congestive heart failure (CHF) and uncontrolled HTN outlines the need for a thorough investigation of cardiac and vascular body systems in this subset of patients.

摘要

合成代谢雄激素类固醇(AAS)的使用一直与职业运动员和健美运动员相关。许多丑闻揭示了合成代谢类固醇在增强人体体格和性能方面的作用,使其在娱乐使用者中极易被滥用。然而,合成代谢类固醇使用存在许多尚未被发现的危险,或者这些危险正逐渐为人所知,尤其是与心血管疾病(CVD)相关的危险。这些风险在被发现之前可能会被掩盖数年,到那时可能为时已晚,无法逆转所有的有害影响。在本文中,我们报告了一例46岁的健康白种男性病例,他承认近期使用过合成代谢类固醇,因左下肢肿胀疼痛、小腿自发瘀伤和气短两天而到急诊科就诊。经过全面评估,发现他患有原发性高血压(HTN)和射血分数降低至30%的心力衰竭。患者接受了关于类固醇使用对其病情可能产生的影响以及未控制的HTN和心力衰竭后果的教育。建议他停止使用类固醇,并开始对这些病症进行药物治疗。最终,使用合成代谢类固醇的患者并没有既定的症状特征,而这例具有模糊症状的患者被发现患有潜在的充血性心力衰竭(CHF)和未控制的HTN的独特病例,凸显了对这部分患者的心脏和血管系统进行全面检查的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b404/11570439/460c442f1e4b/cureus-0016-00000071775-i01.jpg

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