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2型糖尿病患者的牛奶和酸奶摄入量及其与心血管代谢危险因素的关联:福冈糖尿病登记研究

Milk and yogurt consumption and its association with cardiometabolic risk factors in patients with type 2 diabetes: The Fukuoka Diabetes Registry.

作者信息

Yoshinari Masahito, Ohkuma Toshiaki, Iwase Masanori, Kitazono Takanari

机构信息

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Nutr Metab Cardiovasc Dis. 2025 Jan;35(1):103772. doi: 10.1016/j.numecd.2024.10.010. Epub 2024 Oct 17.

Abstract

BACKGROUND AND AIM

The effects of dairy products on cardiometabolic risk factors in patients with diabetes, especially in Asians, have yet to be fully investigated. Therefore, we aimed to characterise the relationship between milk and yogurt consumption and cardiometabolic risk factors in Japanese patients with diabetes.

METHODS AND RESULTS

A total of 4,438 patients with type 2 diabetes were studied. Milk and yogurt consumption was assessed using a validated self-administered diet history questionnaire, and the relationships with cardiometabolic risk factors were evaluated cross-sectionally. High consumption of milk and yogurt was significantly associated with lower body mass index, blood pressure, serum triglyceride concentration and urinary albumin-to-creatinine ratio; and higher low-density lipoprotein-cholesterol concentration (P for trend <0.01). Greater milk and yogurt consumption was also associated with lower likelihood of having metabolic syndrome and chronic kidney disease (CKD) (P for trend <0.001). Multivariable-adjusted odds ratios for metabolic syndrome and CKD in the highest quartile of milk and yogurt consumption, vs. the lowest quartile, were 0.75 (95% confidence interval 0.62-0.91) and 0.72 (0.59-0.89), respectively. However, the likelihood of having a high low-density lipoprotein-cholesterol concentration became higher with greater milk and yogurt consumption (P for trend <0.001).

CONCLUSIONS

Higher milk and yogurt consumption is associated with superior control of cardiovascular risk factors, including CKD, in Japanese patients with type 2 diabetes.

摘要

背景与目的

乳制品对糖尿病患者,尤其是亚洲糖尿病患者心血管代谢危险因素的影响尚未得到充分研究。因此,我们旨在明确日本糖尿病患者牛奶和酸奶摄入量与心血管代谢危险因素之间的关系。

方法与结果

共研究了4438例2型糖尿病患者。使用经过验证的自填式饮食史问卷评估牛奶和酸奶的摄入量,并对其与心血管代谢危险因素的关系进行横断面评估。牛奶和酸奶的高摄入量与较低的体重指数、血压、血清甘油三酯浓度和尿白蛋白与肌酐比值显著相关;以及较高的低密度脂蛋白胆固醇浓度(趋势P<0.01)。更多地摄入牛奶和酸奶还与患代谢综合征和慢性肾脏病(CKD)的可能性较低相关(趋势P<0.001)。牛奶和酸奶摄入量最高四分位数组与最低四分位数组相比,代谢综合征和CKD的多变量调整优势比分别为0.75(95%置信区间0.62-0.91)和0.72(0.59-0.89)。然而,随着牛奶和酸奶摄入量的增加,低密度脂蛋白胆固醇浓度升高的可能性也增加(趋势P<0.001)。

结论

在日本2型糖尿病患者中,较高的牛奶和酸奶摄入量与包括CKD在内的心血管危险因素的更好控制相关。

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