Cortot A, Jobin G, Ducrot F, Aymes C, Giraudeaux V, Modigliani R
Dig Dis Sci. 1986 Apr;31(4):343-8. doi: 10.1007/BF01311667.
We have measured, by an intubation method, gastric evacuation and gastrointestinal absorption of alcohol ingested with a meal in seven healthy nonalcoholic subjects. A homogenized meal containing [14C]PEG and ethanol (1 g/kg body wt) was given intragastrically while saline containing [57CO]vitamin B12 was perfused into the duodenum. Of the ingested alcohol, 39.4 +/- 4.1% was absorbed through the stomach wall during the first postprandial hour and 73.2 +/- 4.2% during the total postcibal period, whereas only 24 +/- 3% was absorbed during the same time in the duodenum. Thus alcohol ingested with a meal is mainly and rapidly absorbed in the stomach; the contribution of the small intestine below the angle of Treitz to alcohol absorption is negligible.
我们采用插管法，对7名健康的非酒精依赖受试者进食时摄入酒精后的胃排空及胃肠道吸收情况进行了测定。向胃内给予含[14C]聚乙二醇（PEG）和乙醇（1克/千克体重）的匀浆餐，同时将含[57Co]维生素B12的生理盐水灌注到十二指肠。摄入的酒精中，餐后第1小时有39.4±4.1%通过胃壁吸收，整个餐后期间有73.2±4.2%被吸收，而在十二指肠中，同一时间内仅有24±3%被吸收。因此，进食时摄入的酒精主要在胃内迅速被吸收；屈氏韧带以下小肠对酒精吸收的贡献可忽略不计。
