Davoli E, Cappellini L, Airoldi L, Fanelli R
Food Chem Toxicol. 1986 Mar;24(3):187-9. doi: 10.1016/0278-6915(86)90227-9.
Serum methanol concentrations were measured in rats and in humans given oral aspartame. The dose given to rats was the FDA's projected 99th percentile daily intake for humans, assuming aspartame were to replace all sucrose sweeteners in the diet (34 mg/kg). Four male adult volunteers each received 500 mg, equivalent to 6-8.7 mg/kg, which is approximately the FDA's estimate of mean daily human consumption. Both treatments caused a rise in serum methanol. In rats the mean peak value was 3.1 mg/litre 1 hr after administration; serum methanol returned to endogenous values 4 hr after treatment. In the men, the mean rise over endogenous values was 1.06 mg/litre after 45 min. Two hours after treatment, serum methanol had returned to basal levels. The temporary serum methanol increase showed peak values within the range of individual basal levels.
对给予口服阿斯巴甜的大鼠和人类测量了血清甲醇浓度。给予大鼠的剂量是美国食品药品监督管理局（FDA）预计的人类每日摄入量第99百分位数，假设阿斯巴甜要替代饮食中的所有蔗糖甜味剂（34毫克/千克）。四名成年男性志愿者每人服用500毫克，相当于6 - 8.7毫克/千克，这大约是FDA对人类每日平均消费量的估计值。两种处理均导致血清甲醇升高。在大鼠中，给药后1小时平均峰值为3.1毫克/升；处理后4小时血清甲醇恢复到内源性值。在男性中，45分钟后内源性值的平均升高为1.06毫克/升。处理后两小时，血清甲醇已恢复到基础水平。血清甲醇的暂时升高显示峰值在个体基础水平范围内。
