Pušnik Jernej, Monzon-Posadas Werner O, Osypchuk Emmanuil, Dubiel Aleksandra Elzbieta, Baum Maximilian, Fehring Paulina, Büning Antonia, Klant Tobias, Streeck Hendrik
Institute of Virology, University Hospital Bonn, Bonn, 53127, Germany.
German Center for Infection Research (DZIF), partner site Bonn-Cologne, Bonn, 53127, Germany.
NPJ Vaccines. 2024 Nov 21;9(1):231. doi: 10.1038/s41541-024-01023-7.
In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.
在本研究中，普什尼克等人调查了XBB.1.5适应性加强针是否能够克服基于野生型的疫苗对SARS-CoV-2免疫的持续印记。研究结果表明，加强疫苗接种后，血浆对同源变体的中和作用增强。在20名个体中的3名个体中观察到针对XBB.1.5变体表面蛋白突变表位的新生体液反应。加强疫苗接种对T细胞反应没有显著影响。
