Bhange Manjusha, Telange Darshan R
Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education & Research (DU), Wardha, Maharashtra, India.
J Hepatocell Carcinoma. 2024 Nov 16;11:2241-2256. doi: 10.2147/JHC.S483619. eCollection 2024.
Hepatocellular carcinoma is the fifth leading cancer in related diseases most commonly in men and women. The curative treatments of liver cancer are short-listed, associated with toxicities and therapeutically. Emerging nanotechnologies exhibited the possibility to treat or target liver cancer. Over the years, to phytosome solid lipid nanoparticles, gold, silver, liposomes, and phospholipid nanoparticles have been produced for liver cancer therapy, and some evidence of their effectiveness has been established. Ideas are limited to the laboratory scale, and in order to develop active targeting of nanomedicine for the clinical aspects, they must be extended to a larger scale. Thus, the current review focuses on previously and presently published research on the creation of phytosomal nanocarriers for the treatment of hepatocellular carcinoma. In hepatocellular carcinoma (HCC), phytosomal nanotherapeutics improve the targeted delivery and bioavailability of phytochemicals to tumor cells, thereby reducing systemic toxicity and increasing therapeutic efficacy. In order to address the intricate molecular processes implicated in HCC, this strategy is essential.
肝细胞癌是男性和女性相关疾病中第五大常见癌症。肝癌的治疗方法有限，且伴有毒性和治疗方面的问题。新兴的纳米技术显示出治疗或靶向肝癌的可能性。多年来，已经制备了用于肝癌治疗的植物脂质体固体脂质纳米粒、金、银、脂质体和磷脂纳米粒，并确立了它们有效性的一些证据。这些想法仅限于实验室规模，为了将纳米医学的主动靶向发展到临床应用，必须扩大规模。因此，当前的综述聚焦于先前和目前发表的关于创建用于治疗肝细胞癌的植物脂质体纳米载体的研究。在肝细胞癌（HCC）中，植物脂质体纳米疗法可提高植物化学物质向肿瘤细胞的靶向递送和生物利用度，从而降低全身毒性并提高治疗效果。为了解决与HCC相关的复杂分子过程，这一策略至关重要。
