Susilawati Yasmiwar, Chaerunisa Anis Yohana, Purwaningsih Hesti
Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia.
Pharmaceutical and Technology Pharmaceutics, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia.
J Adv Pharm Technol Res. 2021 Oct-Dec;12(4):327-334. doi: 10.4103/japtr.JAPTR_100_20. Epub 2021 Oct 20.
Plants have been used as traditional medicine since ancient times for treating the diseases, metabolite active compounds from plants have excellent bioactivity, and pharmacological properties from plants are used as skin whitening agent and antioxidant in multiple mechanisms of action. However, these compounds have physicochemical limitations in terms of its poor solubility and penetration into the cells membrane. Phytosome drug delivery system can be the primary choice to improve the physicochemical properties, which allows increasing the effectiveness. This review aimed to summarize and discuss the phytosome formulations of potential active compounds as skin whitening agent and skin antioxidant, which obtained from Scopus, PubMed, and Google Scholar databases. We assessed that the main purpose of these phytosome formulations was to improve penetration, stability, and solubility of the active compounds. These studies proved that phytosome formulations can improve the physicochemical characteristics and effectiveness of compounds. The phytosome drug delivery system becomes a promising modification technique for natural compounds due to the ability to improve the physicochemical properties and increase the effectiveness. Phytosome formulation could be the excellent approach for cosmeceutical product with good effectivity in the future.
自古以来，植物就被用作传统药物来治疗疾病，植物中的代谢活性化合物具有出色的生物活性，植物的药理特性在多种作用机制中被用作皮肤美白剂和抗氧化剂。然而，这些化合物在溶解度和渗透细胞膜方面存在物理化学局限性。植物脂质体药物递送系统可以作为改善物理化学性质的首要选择，从而提高有效性。本综述旨在总结和讨论从Scopus、PubMed和谷歌学术数据库中获取的潜在活性化合物作为皮肤美白剂和皮肤抗氧化剂的植物脂质体制剂。我们评估这些植物脂质体制剂的主要目的是提高活性化合物的渗透性、稳定性和溶解度。这些研究证明，植物脂质体制剂可以改善化合物的物理化学特性和有效性。由于能够改善物理化学性质并提高有效性，植物脂质体药物递送系统成为一种有前途的天然化合物修饰技术。植物脂质体制剂可能是未来具有良好效果的药妆产品的优秀方法。
