Duan Congcong, Jiang Hongyue, Zhang Shichen, Wang Yixing, Liu Peng, Xu Bin, Tian Wenjing, Han Bing
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.
Jilin Provincial key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China.
Biomater Sci. 2025 Mar 11;13(6):1449-1463. doi: 10.1039/d4bm01260g.
Injuries such as articular cartilage defects are prevalent factors in the development and progression of joint diseases. The discontinuity of the articular surface due to cartilage defects significantly accelerates the onset of arthritis. Cartilage tissue-engineered scaffolds are essential for restoring the continuity of the articular surface. This study presents a dual-network hydrogel, GelMA-FT/Sr, which demonstrates excellent lubrication properties and accelerates the healing of cartilage defects. The hydrogel is composed of a methacrylated gelatin (GelMA) network, an -fluorenylmethoxycarbonyl-L-tryptophan (FT) network, and strontium ions (Sr). The results indicate that the hydrogel exhibits lubricating properties, and the incorporation of Sr extends the degradation time of the hydrogel. Additionally, the hydrogel shows biocompatibility and enhances chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into cartilage. studies further confirm the hydrogel's efficacy in promoting the repair of cartilage defects in a rat model of cartilage injury. In conclusion, the GelMA-FT/Sr hydrogel is a promising scaffold for cartilage tissue engineering, notable for its excellent lubrication properties, ability to recruit stem cells, and effectiveness in facilitating cartilage defect repair.
诸如关节软骨缺损之类的损伤是关节疾病发生和发展的常见因素。由于软骨缺损导致的关节表面不连续会显著加速关节炎的发作。软骨组织工程支架对于恢复关节表面的连续性至关重要。本研究提出了一种双网络水凝胶GelMA-FT/Sr，它具有出色的润滑性能并能加速软骨缺损的愈合。该水凝胶由甲基丙烯酸化明胶（GelMA）网络、芴甲氧羰基-L-色氨酸（FT）网络和锶离子（Sr）组成。结果表明，该水凝胶具有润滑性能，并且Sr的加入延长了水凝胶的降解时间。此外，该水凝胶具有生物相容性，并能增强骨髓间充质干细胞（BMSC）向软骨的软骨形成分化。 研究进一步证实了该水凝胶在软骨损伤大鼠模型中促进软骨缺损修复的功效。总之，GelMA-FT/Sr水凝胶是一种很有前景的软骨组织工程支架，以其出色的润滑性能、招募干细胞的能力以及促进软骨缺损修复的有效性而著称。
