Darenskaya M A, Semendyaev A A, Stupin D A, Kolesnikov S I, Semenova N V, Tukhieva D V, Shcherbatykh A V, Kolesnikova L I
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia.
Bull Exp Biol Med. 2024 Nov;178(1):151-156. doi: 10.1007/s10517-024-06298-3. Epub 2024 Nov 25.
The tissue preparations of the pelvic veins obtained during laparoscopy were examined. The expression of markers of proliferation (Ki-67), apoptosis (p53), and angiogenesis (CD31, CD34), as well as estrogen and progesterone receptors in women with pelvic varicose veins was assessed by the immunohistochemical method. A decrease in the median expression of the proliferation marker (Ki-67) and estrogen and progesterone receptors and simultaneous increase in the expression of apoptosis marker (p53) and activation of angiogenesis processes (markers CD31 and CD34) were observed with increasing the severity of the disease. These data extend our understanding of the pathogenetic mechanisms of pelvic varicose veins and contribute to the development of methods of pathogenetically based targeted therapy.
对腹腔镜检查期间获取的盆腔静脉组织标本进行了检查。采用免疫组织化学方法评估了盆腔静脉曲张女性患者增殖标志物（Ki-67）、凋亡标志物（p53）、血管生成标志物（CD31、CD34）以及雌激素和孕激素受体的表达情况。随着疾病严重程度的增加，观察到增殖标志物（Ki-67）、雌激素和孕激素受体的中位表达降低，同时凋亡标志物（p53）的表达增加以及血管生成过程激活（标志物CD31和CD34）。这些数据扩展了我们对盆腔静脉曲张发病机制的理解，并有助于基于发病机制的靶向治疗方法的开发。
