癫痫女性月经周期中的卵巢激素、抗惊厥药物与癫痫发作
Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
作者信息
Rościszewska D, Buntner B, Guz I, Zawisza L
出版信息
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):47-51. doi: 10.1136/jnnp.49.1.47.
Abstract
The excretion of three oestrogen fractions and progesterone metabolites in 64 female epileptic patients was determined during the menstrual cycle, and in 50 women of this sample serum phenytoin and phenobarbitone levels were measured. A significant decrease of both hormones in epileptic patients was found as compared to a control group. The variations in serum phenytoin levels were greater in females with so-called catamenial epilepsy with a marked fall of drug levels between days 27 and 28 corresponding with an increase of seizure frequency. The effect of progesterone deficit on seizure susceptibility before menstrual bleeding is discussed, and the need of serum anticonvulsant level determination during the premenstrual phase in epileptic women is suggested.
摘要
测定了64名女性癫痫患者在月经周期中三种雌激素组分和孕酮代谢物的排泄情况，并对该样本中的50名女性测量了血清苯妥英和苯巴比妥水平。与对照组相比，癫痫患者体内这两种激素均显著减少。在所谓的经期性癫痫女性中，血清苯妥英水平的变化更大，在第27天至28天期间药物水平显著下降，同时癫痫发作频率增加。讨论了孕酮缺乏对月经出血前癫痫易感性的影响，并建议癫痫女性在经前期测定血清抗惊厥药物水平。
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