Blum D, Brasseur D, Kahn A, Brachet E
J Pediatr Gastroenterol Nutr. 1986 Mar-Apr;5(2):232-5.
Eighteen infants with severe hypernatremic dehydration secondary to acute gastroenteritis were rehydrated during the 1st day with an oral glucose electrolyte solution containing 60 mmol sodium/L at a mean rate of 120 ml/kg/24 h. These 18 children were safely treated with oral therapy alone. No convulsions were observed during treatment. The mean decrease in natremia was 0.32 mmol/L/h, which compared favorably with the mean fall in natremia of 26 other infants in similar initial conditions who were treated intravenously. The present study lends additional support to the opinion that a slow decrease in plasma sodium (less than 0.5 mmol/L/h) helps to avoid seizures during treatment. As no other untoward effects were observed, this study also confirms that oral solutions given at a slow rate can effectively replace intravenous fluids in the majority of such children.
18例继发于急性肠胃炎的重度高钠血症脱水婴儿在第1天接受了口服含60 mmol钠/升葡萄糖电解质溶液的补液治疗，平均补液速度为120毫升/千克/24小时。这18名儿童仅通过口服疗法就得到了安全治疗。治疗期间未观察到惊厥现象。血钠浓度平均每小时下降0.32 mmol/L，与其他26名初始情况相似但接受静脉治疗的婴儿血钠浓度的平均下降情况相比更有利。本研究进一步支持了以下观点：血浆钠缓慢下降（低于0.5 mmol/L/小时）有助于避免治疗期间发生惊厥。由于未观察到其他不良影响，本研究还证实，对于大多数此类儿童，缓慢给予口服溶液可有效替代静脉输液。
