重症肌无力患者抗乙酰胆碱抗体的检测

Detection of anti-acetylcholine antibodies in myasthenic patients.

作者信息

Souan M L, Geffard M, Lebrun-Grandie P, Orgogozo J M

出版信息

Neurosci Lett. 1986 Feb 14;64(1):23-8. doi: 10.1016/0304-3940(86)90657-9.

Abstract

Antibodies, directed against an acetylcholine (ACh) conjugate, were found in the sera of myasthenic patients by using a modified enzyme-linked immunosorbent assay method. Binding of sera from control patients to the conjugate was extremely low. From competition experiments, done with compounds close to ACh, a good antibody specificity for the ACh conjugate was demonstrated in the sera of myasthenic patients. Laboratory tests will be done to help a more precise diagnostic of the disease to be given. These results may also be of value in further understanding of the process of the disease itself.

摘要

通过使用改良的酶联免疫吸附测定法，在重症肌无力患者的血清中发现了针对乙酰胆碱（ACh）偶联物的抗体。对照患者血清与偶联物的结合极低。通过用与ACh相近的化合物进行竞争实验，在重症肌无力患者血清中证明了对ACh偶联物具有良好的抗体特异性。将进行实验室检测以帮助更精确地诊断该疾病。这些结果对于进一步了解疾病本身的过程也可能具有价值。