Ke Fei, Xu Meng-Zhao, Ma Long, Chen Qi-Dong, He Bei-Bei, A Ji-De
The Graduate School, Qinghai University, Xining, China.
Department of Rehabilitation Medicine, Qinghai Provincial People's Hospital, Xining, China.
Front Oncol. 2024 Nov 15;14:1480683. doi: 10.3389/fonc.2024.1480683. eCollection 2024.
Hepatic alveolar echinococcosis is a zoonotic disease with a high incidence in western China, particularly affecting plateau areas such as Qinghai, Tibet, and Xinjiang. Research has indicated the presence of neovascularization in the peripheral infiltration area of hepatic alveolar echinococcosis, with a strong correlation between angiogenesis and vascular endothelial growth factor A (VEGFA) and hypoxia-inducible factor 1-alpha (HIF-1α) overexpression. Given the similarities between hepatic alveolar echinococcosis and liver cancer, current research is focused on treating the disease by targeting related signaling pathways using molecular drugs used for liver cancer. This article aims to summarize the biological regulation of HIF-1α and VEGFA overexpression in angiogenesis related to hepatic alveolar echinococcosis, as well as the impact of the BMP9-ID1 signaling pathway on the expression levels of HIF-1α and VEGFA, providing new insights for potential treatment strategies.
肝泡型包虫病是一种在中国西部高发的人畜共患病，尤其影响青海、西藏和新疆等高海拔地区。研究表明，肝泡型包虫病外周浸润区域存在新生血管形成，血管生成与血管内皮生长因子A（VEGFA）和缺氧诱导因子1α（HIF-1α）的过表达密切相关。鉴于肝泡型包虫病与肝癌之间的相似性，目前的研究集中在使用治疗肝癌的分子药物靶向相关信号通路来治疗该疾病。本文旨在总结肝泡型包虫病相关血管生成中HIF-1α和VEGFA过表达的生物学调控，以及BMP9-ID1信号通路对HIF-1α和VEGFA表达水平的影响，为潜在的治疗策略提供新的见解。
