Ma Liang, Zhu Zhihao, Yu Shijie, Amadi Sidney Moses, Zhao Fei, Zhang Jing, Wang Zhifei
College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, China.
General Surgery, Cancer Center, Department of Hernia Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.
Mater Today Bio. 2024 Nov 13;29:101334. doi: 10.1016/j.mtbio.2024.101334. eCollection 2024 Dec.
The evaluation of thyroid lesions through Fine-Needle Aspiration Biopsy (FNAB) is a common procedure that requires advanced hand manipulation skills. Conventional training models for this procedure lack essential features such as tactile sensation and the ability to repeat punctures similar to those of real organs. To improve the quality of training, we have developed a hydrogel thyroid model that possesses features such as high-water retention and self-healing properties. This model consists of polyvinyl alcohol (PVA), polyacrylic acid (PAA), and trehalose that enhance water retention. By utilizing indirect printing technology, this hydrogel-based thyroid model closely resembles those of porcine thyroid tissue in terms of compression modulus and friction coefficient, exhibiting exceptional conformability, flexibility, and a water retention rate of 94.7 % at 6 h. It also displays a thrust force range of 0-0.98 N during simulated puncture, closely approximating real FNAB operations. This model shows evidence that it effectively simulates thyroid tissue and can be utilized for repetitive FNAB training to enhance the proficiency of medical personnel. Our study focuses on introducing new possibilities for developing advanced materials training models to be utilized in the medical field.
通过细针穿刺活检（FNAB）评估甲状腺病变是一种常见的操作，需要先进的手部操作技能。该操作的传统训练模型缺乏诸如触感以及重复进行与真实器官相似穿刺的能力等基本特征。为了提高训练质量，我们开发了一种具有高保水性和自愈特性等特征的水凝胶甲状腺模型。该模型由增强保水性的聚乙烯醇（PVA）、聚丙烯酸（PAA）和海藻糖组成。通过利用间接打印技术，这种基于水凝胶的甲状腺模型在压缩模量和摩擦系数方面与猪甲状腺组织非常相似，具有出色的贴合性、柔韧性，在6小时时保水率为94.7%。在模拟穿刺过程中，它还显示出0 - 0.98 N的推力范围，非常接近真实的FNAB操作。该模型表明它能有效模拟甲状腺组织，可用于重复性FNAB训练以提高医务人员的熟练度。我们的研究重点是为开发用于医学领域的先进材料训练模型引入新的可能性。
