Duttagupta Suhrit, Chanraud Sandra, Sebag Léa, Mayo Willy, Catheline Gwenaëlle, Poli Mathilde, Liegey Jean-Sebastién, Sibon Igor, Berthoz-Landron Sylvie
University of Bordeaux, INCIA CNRS UMR 5287, Bordeaux, France.
EPHE PSL Research University, Life and Earth Sciences, Paris, France.
Cerebellum. 2024 Dec 4;24(1):1. doi: 10.1007/s12311-024-01757-z.
Stroke patients often experience post-stroke emotional impairments, yet the underlying pathophysiology remains unclear. At the brain level, dysregulation of socio-affective skills should be considered through alterations in brain networks instead of isolated regions. Investigating network alterations may be crucial in explaining emotional or cognitive deficits. In this context, and in line with the dysmetria of thought theory, cerebello-cortical networks' alterations could explain socio-affective functioning. To examine whether impairments in intrinsic functional networks following a cerebellar stroke are associated with poor cognitive and socio-affective performance. Thirty-six cerebellar stroke patients underwent resting-state functional MRI scans at the early stage (T1). They were assessed through a battery of clinical evaluations for cognitive and socio-affective skills. At the chronic stage (T2), evaluations were repeated with additional ecological momentary assessments (EMA) for emotional behavior. The global efficiencies of four resting-state functional brain networks associated with the cerebellum were determined. Patients were classified into subgroups of high and low functioning based on the evaluations and compared. Poorer global efficiency in the default-mode network was present in the subgroup with higher depression (T1: p = 0.034, T2: p = 0.006) and low EMA positive mood (p = 0.048), while lower efficiency in the dorsal attentional network was shown in the subgroup with lower verbal memory (T1: p = 0.004, T2: p = 0.048). Disruptions in intrinsic functional networks are linked to poorer cognition and emotion for some cerebellar stroke patients, partially supporting the theory of 'dysmetria of thought'.
中风患者经常经历中风后的情绪障碍，但其潜在的病理生理学仍不清楚。在大脑层面，社会情感技能的失调应通过大脑网络的改变而非孤立的区域来考虑。研究网络改变对于解释情绪或认知缺陷可能至关重要。在此背景下，与思维辨距障碍理论一致，小脑 - 皮质网络的改变可以解释社会情感功能。为了研究小脑中风后内在功能网络的损伤是否与认知和社会情感表现不佳有关。36名小脑中风患者在早期阶段（T1）接受了静息态功能磁共振成像扫描。他们通过一系列认知和社会情感技能的临床评估进行评估。在慢性阶段（T2），重复评估并增加了对情绪行为的生态瞬时评估（EMA）。确定了与小脑相关的四个静息态功能脑网络的全局效率。根据评估将患者分为高功能和低功能亚组并进行比较。在抑郁程度较高的亚组中，默认模式网络的全局效率较低（T1：p = 0.034，T2：p = 0.006），EMA积极情绪较低（p = 0.048），而在言语记忆较低的亚组中，背侧注意网络的效率较低（T1：p = 0.004，T2：p = 0.048）。对于一些小脑中风患者，内在功能网络的破坏与较差的认知和情绪有关，部分支持了“思维辨距障碍”理论。
