Rosemurgy A S, Schraut W H
Am J Surg. 1986 Apr;151(4):470-5. doi: 10.1016/0002-9610(86)90106-6.
Using a rat model of accessory small bowel transplantation, the histologic sequence of both acute and chronic rejection in intestinal allograft rejection has been defined. Histologically, all allografts were normal for the first 5 postoperative days. Allografts with caval venous drainage were subject to acute rejection. By 6 to 7 days postoperatively, plasma cells and lymphocytes infiltrated the lamina propria of these grafts (phase I). By 8 to 9 days postoperatively, the cellular infiltration intensified and was associated with villous blunting and scattered epithelial sloughing (phase II). By the 10th day, complete mucosal destruction developed, with heavy transmural infiltration by lymphocytes, plasma cells, and polymorphonuclear leukocytes (phase III). This histologic end point of acute graft rejection was accompanied by death of the host. Grafts with portal venous drainage underwent a similar, although less rapid, sequence of histologic changes (phase I 6 to 9 days, phase II 10 to 13 days, phase III 13 or more days) resulting in graft fibrosis and encapsulation. Some variability was seen among different areas of a given circumferential cross section taken from grafts in phases I and II. Studying circumferential cross sections allowed correct classification into the appropriate phases.
利用辅助性小肠移植大鼠模型，已明确肠道同种异体移植中急性和慢性排斥反应的组织学变化过程。组织学上，所有同种异体移植物在术后第1天至第5天均正常。采用腔静脉引流的同种异体移植物会发生急性排斥反应。术后6至7天，浆细胞和淋巴细胞浸润这些移植物的固有层（I期）。术后8至9天，细胞浸润加剧，并伴有绒毛变钝和散在的上皮脱落（II期）。到第10天，出现完全的黏膜破坏，淋巴细胞、浆细胞和多形核白细胞重度透壁浸润（III期）。急性移植物排斥反应的这一组织学终点伴随着宿主死亡。采用门静脉引流的移植物经历了类似但较缓慢的组织学变化过程（I期为6至9天，II期为10至13天，III期为13天或更长时间），导致移植物纤维化和包囊形成。在I期和II期从移植物获取的给定圆周横截面的不同区域之间观察到一些差异。研究圆周横截面可实现正确分类至相应阶段。
