Radiomics As Biomarkers for the Treatment of Non-small Cell Lung Cancer With Stereotactic Body Radiation Therapy: A Review of Concepts.

Stereotactic body radiation therapy (SBRT) is currently the alternative for inoperable early-stage and oligometastatic non-small cell lung cancer (NSCLC) patients. While most patients are good responders among this specific group, some patients do not experience the benefits of this treatment. Even though physicians use clinical variables and semantic radiological features to make treatment decisions, medical images contain a wealth of personalized pathophysiological information that can be extracted and used for clinical decision support systems. In the form of radiomics features, details unique to each patient's medical scans can be utilized to create predictive models and to identify biomarking signatures. Then, these tools and indices can predict treatment outcomes and categorize patients to the most optimal treatment regimen. A conceptual review of relevant topics centered around the identification and development of radiomic-based biomarkers for SBRT-treated NSCLC was conducted. To begin with, an overview of the nature and management of non-small cell lung cancer was provided. To continue, biomarkers were defined in the context of cancer care. Then, the uses of stereotactic body radiation therapy in the treatment of NSCLC were further explained. Finally, the study of radiomics was discussed, and the uses and limitations of radiomic features and ML for SBRT-treated NSCLC were expanded upon. Radiomics-based biomarkers and predictive algorithmic models can potentially improve the SBRT treatment of early-stage and oligometastatic NSCLC by providing personalized support systems to healthcare professionals. While many institutions are attempting to optimize their biomarkers and AI-based tools for clinical use, additional prospective studies are needed to properly ensure their efficacy. As such, the improvements made in the field of personalized medicine are promising.