Chiba Nodoka, Suzuki Shinya, Enriquez-Vera Daniel, Utsunomiya Atae, Kubuki Yoko, Hidaka Tomonori, Shimoda Kazuya, Nakahata Shingo, Yamada Takuji, Morishita Kazuhiro
School of Life Science and Technology, Tokyo Institute of Technology, Meguro, Tokyo, Japan.
Division of HTLV-1/ATL Carcinogenesis and Therapeutics, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
Heliyon. 2024 Oct 2;10(20):e38507. doi: 10.1016/j.heliyon.2024.e38507. eCollection 2024 Oct 30.
Adult T-cell leukemia/lymphoma (ATLL) is a refractory blood cancer with severe immunodeficiency resulting from retroviral infection. ATLL develops in only 5 % of HTLV-1-infected individuals, but the entire mechanism of ATLL progression remains unknown. Since recent studies have reported that the gut microbiome influences the progression of various diseases, we hypothesized that ATLL is also related to the gut microbiome and aimed to investigate this relationship. We analyzed the taxonomic and functional profiles of the gut microbiota of ATLL patients (n = 28) and HTLV-1-infected individuals (n = 37). We found that the succinic semialdehyde (SSA) synthesis pathway was significantly enriched in the gut microbiome of ATLL patients (P = 0.000682), and , whose abundance was significantly greater in ATLL patients and high-risk HTLV-1-infected individuals (P = 0.0326), was the main contributor to this pathway. Administration of SSAs to ATLL cell lines resulted in significant cell proliferation. Herein, we propose that the gut microbiome can regulate ATLL progression via metabolites.
成人T细胞白血病/淋巴瘤（ATLL）是一种由逆转录病毒感染导致严重免疫缺陷的难治性血癌。仅5%的人类嗜T淋巴细胞病毒1型（HTLV-1）感染者会发展为ATLL，但ATLL进展的完整机制仍不清楚。由于最近的研究报告称肠道微生物群会影响各种疾病的进展，我们推测ATLL也与肠道微生物群有关，并旨在研究这种关系。我们分析了ATLL患者（n = 28）和HTLV-1感染者（n = 37）肠道微生物群的分类学和功能特征。我们发现，琥珀半醛（SSA）合成途径在ATLL患者的肠道微生物群中显著富集（P = 0.000682），并且作为该途径的主要贡献者，其丰度在ATLL患者和高危HTLV-1感染者中显著更高（P = 0.0326）。向ATLL细胞系施用SSA会导致显著的细胞增殖。在此，我们提出肠道微生物群可通过代谢产物调节ATLL进展。
