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通过高效液相色谱法从动脉粥样硬化主动脉中分离出的过氧化脂质。

Peroxidized lipids isolated by HPLC from atherosclerotic aorta.

作者信息

Mowri H, Chinen K, Ohkuma S, Takano T

出版信息

Biochem Int. 1986 Feb;12(2):347-52.

PMID:3964289
Abstract

Conjugated dienes of fatty acids were detected in cholesterol esters in lipid droplets prepared from atherosclerotic aorta of WHHL rabbits. Two peroxidized fatty acids were recovered by reverse phase HPLC. These peroxidized fatty acids showed maximum absorption at 233 nm, suggesting that they were peroxidized lipids containing cis-trans conjugated diene, and one of them was shown to be 13-hydroxy octadecadienoic acid.

摘要

在从WHHL兔动脉粥样硬化主动脉制备的脂滴中的胆固醇酯中检测到脂肪酸的共轭二烯。通过反相高效液相色谱法回收了两种过氧化脂肪酸。这些过氧化脂肪酸在233nm处显示出最大吸收,表明它们是含有顺反共轭二烯的过氧化脂质,其中一种被证明是13-羟基十八碳二烯酸。

相似文献

1
Peroxidized lipids isolated by HPLC from atherosclerotic aorta.通过高效液相色谱法从动脉粥样硬化主动脉中分离出的过氧化脂质。
Biochem Int. 1986 Feb;12(2):347-52.
2
Chemical and physiochemical comparison of advanced atherosclerotic lesions of similar size and cholesterol content in cholesterol-fed New Zealand White and Watanabe Heritable Hyperlipidemic rabbits.在喂食胆固醇的新西兰白兔和渡边遗传性高脂血症兔中,对大小和胆固醇含量相似的晚期动脉粥样硬化病变进行化学和物理化学比较。
Lab Invest. 1990 Feb;62(2):213-22.
3
Monoclonal DLR1a/104G antibody recognizing peroxidized lipoproteins in atherosclerotic lesions.识别动脉粥样硬化病变中过氧化脂蛋白的单克隆DLR1a/104G抗体。
Biochim Biophys Acta. 1988 Nov 25;963(2):208-14. doi: 10.1016/0005-2760(88)90282-2.
4
Lipid analysis and fatty acid profiles of individual arterial atherosclerotic plaques.单个动脉粥样硬化斑块的脂质分析和脂肪酸谱
Anal Biochem. 1990 Jun;187(2):273-6. doi: 10.1016/0003-2697(90)90456-j.
5
Mature human atherosclerotic plaque contains peroxidized phosphatidylcholine as a major lipid peroxide.成熟的人类动脉粥样硬化斑块含有过氧化磷脂酰胆碱作为主要的脂质过氧化物。
Life Sci. 1996;58(9):735-40. doi: 10.1016/0024-3205(95)02351-8.
6
[Increase in the lipid peroxide content in the blood and aortas of rabbits with experimental atherosclerosis].[实验性动脉粥样硬化家兔血液及主动脉中脂质过氧化物含量的增加]
Vopr Med Khim. 1976 Jul-Aug;22(4):513-7.
7
[Histochromatography as an accessory method of lipid histochemistry].
Acta Histochem Suppl. 1975;15:87-100.
8
[Physical state of lipids accumulated in atherosclerotic lesions (author's transl)].动脉粥样硬化病变中积聚脂质的物理状态(作者译)
Pathol Biol (Paris). 1978 May-Jun;26(5):249-53.
9
Phospholipid peroxidation after 60 min of global ischaemia and 10 min of reperfusion. A study in the isolated rat heart.全脑缺血60分钟及再灌注10分钟后的磷脂过氧化。一项在离体大鼠心脏上的研究。
J Mol Cell Cardiol. 1994 May;26(5):569-78. doi: 10.1006/jmcc.1994.1069.
10
[Lipid distribution in the rabbit aorta in dietetic cholesterol atherosis].[饮食性胆固醇动脉粥样硬化中兔主动脉的脂质分布]
Frankf Z Pathol. 1966;75(2):126-40.

引用本文的文献

1
The History of the WHHL Rabbit, an Animal Model of Familial Hypercholesterolemia (I) - Contribution to the Elucidation of the Pathophysiology of Human Hypercholesterolemia and Coronary Heart Disease.载脂蛋白 E 基因缺陷兔模型的建立及其在动脉粥样硬化研究中的应用
J Atheroscler Thromb. 2020 Feb 1;27(2):105-118. doi: 10.5551/jat.RV17038-1. Epub 2019 Nov 21.
2
Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells.胆固醇接受体调节泡沫细胞的脂类组。
Int J Mol Sci. 2019 Aug 2;20(15):3784. doi: 10.3390/ijms20153784.
3
Oxidized low-density lipoprotein.
氧化型低密度脂蛋白
Methods Mol Biol. 2010;610:403-17. doi: 10.1007/978-1-60327-029-8_24.
4
Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.谷胱甘肽过氧化物酶增强了S-亚硝基硫醇对血小板功能的抑制作用。
J Clin Invest. 1995 Jul;96(1):394-400. doi: 10.1172/JCI118047.
5
Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.普罗布考的抗动脉粥样硬化作用与其降胆固醇作用无关:体内抗氧化剂可选择性抑制富含巨噬细胞的脂肪条纹中低密度脂蛋白降解并减缓渡边遗传性高脂血症兔动脉粥样硬化进展的证据。
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7725-9. doi: 10.1073/pnas.84.21.7725.