Moshfeghinia Reza, Arman Ali, Sobhi Navid, Mahmoudinezhad Golnoush, Molavi Vardanjani Hossein
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
MD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Front Public Health. 2024 Nov 22;12:1477411. doi: 10.3389/fpubh.2024.1477411. eCollection 2024.
Keratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between depression and KC via a systematic review and meta-analysis.
Five electronic medical databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) were systematically queried for English-language records from their inception to January 8, 2024. We include observational studies that measured the risk of depression or compared depression scores in KC patients in comparison to healthy ones. The Newcastle-Ottawa Quality Assessment Scale was utilized to assess bias risk in the included studies. Random-effect modeling was applied for meta-analysis (STATA-17).
Out of the 159 documents retrieved, seven articles were deemed relevant after screening. An analysis involving 83 KC patients and 3,186 controls indicated that KC participants had significantly higher depression scores [SMD: 0.71 [0.31, 1.11]; < 0.01, : 52.7%]. However, a meta-analysis of four studies comparing depression rates in KC patients ( = 23,838) to control groups ( = 73,482) found no increased risk of depression among KC patients compared to controls [OR: 1.13 [0.66, 1.94]; = 0.65, : 95.35%].
While KC patients exhibit significantly higher depression scores compared to controls, a meta-analysis indicates no increased overall risk of depression among KC patients. These findings highlight the complexity of the relationship between keratoconus and mental health, warranting further investigation.
PROSPERO, identifier, CRD42024502247, available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247.
圆锥角膜（KC）是一种慢性角膜疾病，通常在成年早期发病，可能会对患者的心理健康产生不良影响。关于抑郁症与圆锥角膜之间关联的证据存在争议。因此，我们通过系统评价和荟萃分析来研究抑郁症与圆锥角膜之间的关联。
对五个电子医学数据库（PubMed、Scopus、PsycINFO、Web of Science和CINAHL Complete）进行系统检索，以获取从建库至2024年1月8日的英文记录。我们纳入了测量抑郁症风险或比较圆锥角膜患者与健康人抑郁评分的观察性研究。采用纽卡斯尔-渥太华质量评估量表来评估纳入研究中的偏倚风险。荟萃分析采用随机效应模型（STATA-17）。
在检索到的159篇文献中，筛选后有7篇文章被认为相关。一项涉及83例圆锥角膜患者和3186例对照的分析表明，圆锥角膜患者的抑郁评分显著更高[标准化均数差：0.71[0.31, 1.11]；P<0.01，I²：52.7%]。然而，一项对四项研究的荟萃分析，比较了圆锥角膜患者（n = 23838）与对照组（n = 73482）的抑郁症发病率，发现与对照组相比，圆锥角膜患者患抑郁症的风险并未增加[比值比：1.13[0.66, 1.94]；P = 0.65，I²：95.35%]。
虽然与对照组相比，圆锥角膜患者的抑郁评分显著更高，但荟萃分析表明圆锥角膜患者患抑郁症的总体风险并未增加。这些发现凸显了圆锥角膜与心理健康之间关系的复杂性，值得进一步研究。
PROSPERO，标识符，CRD42024502247，可在：https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247获取。
