MIBiG 4.0：通过全球合作推进生物合成基因簇管理
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.
作者信息
Zdouc Mitja M, Blin Kai, Louwen Nico L L, Navarro Jorge, Loureiro Catarina, Bader Chantal D, Bailey Constance B, Barra Lena, Booth Thomas J, Bozhüyük Kenan A J, Cediel-Becerra José D D, Charlop-Powers Zachary, Chevrette Marc G, Chooi Yit Heng, D'Agostino Paul M, de Rond Tristan, Del Pup Elena, Duncan Katherine R, Gu Wenjia, Hanif Novriyandi, Helfrich Eric J N, Jenner Matthew, Katsuyama Yohei, Korenskaia Aleksandra, Krug Daniel, Libis Vincent, Lund George A, Mantri Shrikant, Morgan Kalindi D, Owen Charlotte, Phan Chin-Soon, Philmus Benjamin, Reitz Zachary L, Robinson Serina L, Singh Kumar Saurabh, Teufel Robin, Tong Yaojun, Tugizimana Fidele, Ulanova Dana, Winter Jaclyn M, Aguilar César, Akiyama Daniel Y, Al-Salihi Suhad A A, Alanjary Mohammad, Alberti Fabrizio, Aleti Gajender, Alharthi Shumukh A, Rojo Mariela Y Arias, Arishi Amr A, Augustijn Hannah E, Avalon Nicole E, Avelar-Rivas J Abraham, Axt Kyle K, Barbieri Hellen B, Barbosa Julio Cesar J, Barboza Segato Lucas Gabriel, Barrett Susanna E, Baunach Martin, Beemelmanns Christine, Beqaj Dardan, Berger Tim, Bernaldo-Agüero Jordan, Bettenbühl Sandra M, Bielinski Vincent A, Biermann Friederike, Borges Ricardo M, Borriss Rainer, Breitenbach Milena, Bretscher Kevin M, Brigham Michael W, Buedenbender Larissa, Bulcock Brodie W, Cano-Prieto Carolina, Capela João, Carrion Victor J, Carter Riley S, Castelo-Branco Raquel, Castro-Falcón Gabriel, Chagas Fernanda O, Charria-Girón Esteban, Chaudhri Ayesha Ahmed, Chaudhry Vasvi, Choi Hyukjae, Choi Yukyung, Choupannejad Roya, Chromy Jakub, Donahey Melinda S Chue, Collemare Jérôme, Connolly Jack A, Creamer Kaitlin E, Crüsemann Max, Cruz Andres Arredondo, Cumsille Andres, Dallery Jean-Felix, Damas-Ramos Luis Caleb, Damiani Tito, de Kruijff Martinus, Martín Belén Delgado, Sala Gerardo Della, Dillen Jelle, Doering Drew T, Dommaraju Shravan R, Durusu Suhan, Egbert Susan, Ellerhorst Mark, Faussurier Baptiste, Fetter Artem, Feuermann Marc, Fewer David P, Foldi Jonathan, Frediansyah Andri, Garza Erin A, Gavriilidou Athina, Gentile Andrea, Gerke Jennifer, Gerstmans Hans, Gomez-Escribano Juan Pablo, González-Salazar Luz A, Grayson Natalie E, Greco Claudio, Gomez Juan E Gris, Guerra Sebastian, Flores Shaday Guerrero, Gurevich Alexey, Gutiérrez-García Karina, Hart Lauren, Haslinger Kristina, He Beibei, Hebra Teo, Hemmann Jethro L, Hindra Hindra, Höing Lars, Holland Darren C, Holme Jonathan E, Horch Therese, Hrab Pavlo, Hu Jie, Huynh Thanh-Hau, Hwang Ji-Yeon, Iacovelli Riccardo, Iftime Dumitrita, Iorio Marianna, Jayachandran Sidharth, Jeong Eunah, Jing Jiayi, Jung Jung J, Kakumu Yuya, Kalkreuter Edward, Kang Kyo Bin, Kang Sangwook, Kim Wonyong, Kim Geum Jin, Kim Hyunwoo, Kim Hyun Uk, Klapper Martin, Koetsier Robert A, Kollten Cassandra, Kovács Ákos T, Kriukova Yelyzaveta, Kubach Noel, Kunjapur Aditya M, Kushnareva Aleksandra K, Kust Andreja, Lamber Jessica, Larralde Martin, Larsen Niels J, Launay Adrien P, Le Ngoc-Thao-Hien, Lebeer Sarah, Lee Byung Tae, Lee Kyungha, Lev Katherine L, Li Shu-Ming, Li Yong-Xin, Licona-Cassani Cuauhtémoc, Lien Annette, Liu Jing, Lopez Julius Adam V, Machushynets Nataliia V, Macias Marla I, Mahmud Taifo, Maleckis Matiss, Martinez-Martinez Añadir Maharai, Mast Yvonne, Maximo Marina F, McBride Christina M, McLellan Rose M, Bhatt Khyati Mehta, Melkonian Chrats, Merrild Aske, Metsä-Ketelä Mikko, Mitchell Douglas A, Müller Alison V, Nguyen Giang-Son, Nguyen Hera T, Niedermeyer Timo H J, O'Hare Julia H, Ossowicki Adam, Ostash Bohdan O, Otani Hiroshi, Padva Leo, Paliyal Sunaina, Pan Xinya, Panghal Mohit, Parade Dana S, Park Jiyoon, Parra Jonathan, Rubio Marcos Pedraza, Pham Huong T, Pidot Sacha J, Piel Jörn, Pourmohsenin Bita, Rakhmanov Malik, Ramesh Sangeetha, Rasmussen Michelle H, Rego Adriana, Reher Raphael, Rice Andrew J, Rigolet Augustin, Romero-Otero Adriana, Rosas-Becerra Luis Rodrigo, Rosiles Pablo Y, Rutz Adriano, Ryu Byeol, Sahadeo Libby-Ann, Saldanha Murrel, Salvi Luca, Sánchez-Carvajal Eduardo, Santos-Medellin Christian, Sbaraini Nicolau, Schoellhorn Sydney M, Schumm Clemens, Sehnal Ludek, Selem Nelly, Shah Anjali D, Shishido Tania K, Sieber Simon, Silviani Velina, Singh Garima, Singh Hemant, Sokolova Nika, Sonnenschein Eva C, Sosio Margherita, Sowa Sven T, Steffen Karin, Stegmann Evi, Streiff Alena B, Strüder Alena, Surup Frank, Svenningsen Tiziana, Sweeney Douglas, Szenei Judit, Tagirdzhanov Azat, Tan Bin, Tarnowski Matthew J, Terlouw Barbara R, Rey Thomas, Thome Nicola U, Torres Ortega Laura Rosina, Tørring Thomas, Trindade Marla, Truman Andrew W, Tvilum Marie, Udwary Daniel W, Ulbricht Christoph, Vader Lisa, van Wezel Gilles P, Walmsley Max, Warnasinghe Randika, Weddeling Heiner G, Weir Angus N M, Williams Katherine, Williams Sam E, Witte Thomas E, Rocca Steffaney M Wood, Yamada Keith, Yang Dong, Yang Dongsoo, Yu Jingwei, Zhou Zhenyi, Ziemert Nadine, Zimmer Lukas, Zimmermann Alina, Zimmermann Christian, van der Hooft Justin J J, Linington Roger G, Weber Tilmann, Medema Marnix H
机构信息
Bioinformatics Group, Wageningen University & Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Building 220, Søltofts Plads, 2800 Kongens Lyngby, Denmark.
出版信息
Nucleic Acids Res. 2025 Jan 6;53(D1):D678-D690. doi: 10.1093/nar/gkae1115.
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.
特殊代谢产物或次生代谢产物是具有生物来源的小分子，通常具有强大的生物活性，在农业、工程和医学领域有应用。通常，这些天然产物的生物合成由一组共同调控且物理上成簇的基因控制，这些基因被称为生物合成基因簇（BGCs）。为了以标准化且机器可读的方式共享有关BGCs的信息，2015年启动了生物合成基因簇最小信息（MIBiG）数据标准和数据库。自构思以来，MIBiG一直在定期更新，以扩大数据覆盖范围，并跟上天然产物研究的创新步伐。在此，我们描述MIBiG版本4.0，这是对数据库和基础数据标准的一次重大更新。在一项大规模的社区注释工作中，267名贡献者进行了8304次编辑，创建了557个新条目并修改了590个现有条目，使得MIBiG中经过整理的条目总数达到了3059个。特别注重确保高数据质量，使用新开发的自定义提交门户原型进行自动数据验证，并辅以新颖的同行评审模型。MIBiG 4.0还朝着滚动发布模式和科学界更广泛参与的方向迈进。可通过https://mibig.secondarymetabolites.org/在线访问MIBiG 4.0。
Zotero 插件