成人膳食叶酸摄入量与严重头痛或偏头痛之间的关联：一项基于美国国家健康与营养检查调查的横断面研究
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
作者信息
Zhao Dehua, Long Xiaoqing, Wang Jisheng
机构信息
Department of Clinical Pharmacy, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, Sichuan, China.
出版信息
Front Nutr. 2024 Nov 26;11:1456502. doi: 10.3389/fnut.2024.1456502. eCollection 2024.
BACKGROUND
The aim of this study was to assess the association between dietary folate intake and severe headache or migraine.
METHODS
This cross-sectional study utilized the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2004. Weighted logistic regression models, restricted cubic spline (RCS) regression, sensitivity analysis, and stratified analyses were performed to evaluate the association between dietary folate intake and severe headache or migraine.
RESULTS
A total of 4,107 participants were included, with 704 individuals (17.14%) experienced severe headache or migraine. After adjusting for all covariates, an independent association was found between dietary folate intake and severe headache or migraine (OR = 0.77, 95% CI: 0.64-0.93, = 0.005). When folate intake was categorized, individuals in Q2 (251.21-356.00 μg/d), Q3 (356.19-514.00 μg/d), and Q4 (≥515.00 μg/d) had ORs of 0.95 (95% CI: 0.75-1.20, = 0.660), 0.86 (95% CI: 0.67-1.12, = 0.266), and 0.65 (95% CI: 0.48-0.89, = 0.007), respectively, compared to those in Q1 (≤251.00 μg/d). The RCS regression showed a linear negative relationship between dietary folate intake and severe headache or migraine. Stratified and sensitivity analyses yielded similar results.
CONCLUSION
There was a linear negative relationship between dietary folate intake and migraine.
背景
本研究旨在评估膳食叶酸摄入量与严重头痛或偏头痛之间的关联。
方法
这项横断面研究利用了1999年至2004年的美国国家健康与营养检查调查（NHANES）数据。采用加权逻辑回归模型、受限立方样条（RCS）回归、敏感性分析和分层分析来评估膳食叶酸摄入量与严重头痛或偏头痛之间的关联。
结果
共纳入4107名参与者，其中704人（17.14%）经历过严重头痛或偏头痛。在对所有协变量进行调整后，发现膳食叶酸摄入量与严重头痛或偏头痛之间存在独立关联（比值比[OR]=0.77，95%置信区间[CI]：0.64 - 0.93，P = 0.005）。当对叶酸摄入量进行分类时，与第一四分位数（≤251.00μg/d）的个体相比，第二四分位数（251.21 - 356.00μg/d）、第三四分位数（356.19 - 514.00μg/d）和第四四分位数（≥515.00μg/d）的个体的OR分别为0.95（95%CI：0.75 - 1.20，P = 0.660）、0.86（95%CI：0.67 - 1.12，P = 0.266）和0.65（95%CI：0.48 - 0.89，P = 0.007）。RCS回归显示膳食叶酸摄入量与严重头痛或偏头痛之间呈线性负相关。分层分析和敏感性分析得出了相似的结果。
结论
膳食叶酸摄入量与偏头痛之间存在线性负相关。
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