两例眼内未分化多形性肉瘤
Two Cases of Intraocular Undifferentiated Pleomorphic Sarcoma.
作者信息
Khatab Sodaba, Colijn Johanna Maria, Naus Nicole, Verdijk Robert M, Hötte Gijsbert
机构信息
Department of Oculoplastic, Orbital and Lacrimal Surgery, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
出版信息
Ocul Oncol Pathol. 2024 Dec;10(4):227-233. doi: 10.1159/000541063. Epub 2024 Sep 27.
INTRODUCTION
Undifferentiated pleomorphic sarcoma (UPS), formerly known as malignant fibrous histiocytoma, is a high-grade soft tissue sarcoma arising from mesenchymal stem cells. UPSs are rare and account for about 5% of all soft tissue sarcoma. UPSs arising in the head and neck are especially rare, comprising 1-3% of all UPSs.
CASE PRESENTATION
In this report, we describe 2 cases of intraocular UPS. Both cases concern 68-year-old males: one developing a UPS in an eviscerated socket after a chronic fibrinous inflammation and the other years after ocular trauma.
CONCLUSION
Our cases may support the hypothesis of chronic inflammation playing a role in sarcoma formation as they are characterized by a longstanding history of (surgical) trauma with signs of chronic inflammation and phthisis bulbi.
引言
未分化多形性肉瘤（UPS），以前称为恶性纤维组织细胞瘤，是一种起源于间充质干细胞的高级别软组织肉瘤。UPS很罕见，约占所有软组织肉瘤的5%。头颈部发生的UPS尤其罕见，占所有UPS的1-3%。
病例报告
在本报告中，我们描述了2例眼内UPS病例。两例均为68岁男性：一例在慢性纤维蛋白性炎症后于眼球摘除后的眼窝内发生UPS，另一例在眼外伤多年后发生。
结论
我们的病例可能支持慢性炎症在肉瘤形成中起作用的假说，因为它们的特征是有（手术）创伤的长期病史以及慢性炎症和眼球痨的迹象。
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