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基于组学的技术在家禽肉研究中的应用。

Omics based technology application in poultry meat research.

作者信息

Zhou Huaijun, Quach Austin, Nair Mahesh, Abasht Behnam, Kong Byungwhi, Bowker Brian

机构信息

Department of Animal Science, University of California, Davis, Davis, CA, USA.

Dalton Bioanalytics Inc., Los Angeles, CA, USA.

出版信息

Poult Sci. 2025 Jan;104(1):104643. doi: 10.1016/j.psj.2024.104643. Epub 2024 Dec 5.

Abstract

Omics techniques, including genomics, transcriptomics, proteomics, metabolomics, and lipidomics, analyze entire sets of biological molecules to seek comprehensive knowledge on a particular phenotype. These approaches have been extensively utilized to identify both biomarkers and biological mechanisms for various physiological conditions in livestock and poultry. The purpose of this symposium was not only to focus on how recent omics technologies can be used to gather, integrate, and interpret data produced by various methodologies in poultry research, but also to highlight how omics and bioinformatics have increased our understanding of poultry meat quality problems and other complex traits. This Poultry Science Association symposium paper includes 5 sections that cover: 1) functional annotation of cis-regulatory elements in the genome informs genetic control of complex traits in poultry, 2) mass spectrometry for proteomics, metabolomics, and lipidomics, 3) proteomic approaches to investigate meat quality, 4) spatial transcriptomics and metabolomics studies of wooden breast disease, and 5) multiomics analyses on chicken meat quality and spaghetti meat. These topics provide insights into the molecular components that contribute to the structure, function, and dynamics of the underlying mechanisms influencing meat quality traits, including chicken breast myopathies. This information will ultimately contribute to improving the quality and composition of poultry products.

摘要

组学技术,包括基因组学、转录组学、蛋白质组学、代谢组学和脂质组学,分析整套生物分子,以寻求关于特定表型的全面知识。这些方法已被广泛用于识别畜禽各种生理状况的生物标志物和生物学机制。本次研讨会的目的不仅是关注如何利用最新的组学技术来收集、整合和解释家禽研究中各种方法产生的数据,还在于强调组学和生物信息学如何增进了我们对禽肉品质问题和其他复杂性状的理解。这篇家禽科学协会研讨会论文包括5个部分,内容涵盖:1)基因组中顺式调控元件的功能注释为家禽复杂性状的遗传控制提供信息,2)蛋白质组学、代谢组学和脂质组学的质谱分析,3)研究肉质的蛋白质组学方法,4)木胸病的空间转录组学和代谢组学研究,5)鸡肉品质和意式肉酱肉的多组学分析。这些主题深入探讨了影响肉质性状(包括鸡胸肌病)的潜在机制的结构、功能和动态的分子组成部分。这些信息最终将有助于提高家禽产品的质量和成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5dc/11697050/de0d8b65076e/gr1.jpg

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