Gonggrijp Bodine M A, van de Weijer Steve G A, Bijleveld Catrien C J H, Boomsma Dorret I, van Dongen Jenny
Department of Biological Psychology, Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, Netherlands.
Netherlands Institute for the Study of Crime and Law Enforcement (NSCR), Amsterdam, Netherlands.
Behav Genet. 2025 May;55(3):215-230. doi: 10.1007/s10519-024-10211-z. Epub 2024 Dec 11.
We aimed to understand the long-term impact of negative life events on epigenetic aging in 1783 adults from the Netherlands Twin Register, analyzing five epigenetic biomarkers (Hannum, Horvath, PhenoAge, GrimAge, DunedinPACE) and a series of negative life events, including victimization and economic hardship. In population-level analyses, associations between a higher number of negative life events (particularly financial adversities, sexual crimes, and job loss) were seen for the GrimAge biomarker. The association between the number of negative life events and financial problems and epigenetic age acceleration measured by the GrimAge biomarker persisted after adjusting for BMI, smoking, and white blood cell counts. In monozygotic twin pairs discordant for negative life events (263 pairs) the associations were diminished, indicating that the population associations may be confounded by shared familial (genetic and environmental) factors. These findings underscore the intricate link between environmental stressors and biological aging, stressing the need for comprehensive studies considering both genetic and environmental influences.
我们旨在了解负面生活事件对来自荷兰双胞胎登记处的1783名成年人表观遗传衰老的长期影响，分析了五种表观遗传生物标志物（汉纳姆、霍瓦斯、表型年龄、格里姆年龄、达尼丁PACE）以及一系列负面生活事件，包括受害经历和经济困难。在人群水平分析中，对于格里姆年龄生物标志物，发现负面生活事件数量较多（特别是经济困境、性犯罪和失业）之间存在关联。在调整了体重指数、吸烟情况和白细胞计数后，负面生活事件数量与财务问题以及由格里姆年龄生物标志物测量的表观遗传年龄加速之间的关联仍然存在。在负面生活事件不一致的同卵双胞胎对（263对）中，这种关联减弱，表明人群关联可能受到共同家族（遗传和环境）因素的混淆。这些发现强调了环境应激源与生物衰老之间的复杂联系，强调需要进行综合研究，同时考虑遗传和环境影响。
