Tian He, Fan Qian, Gao Wenjing, Wang Yan
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Nankai University Eye Institute, Nankai University Affiliated Eye Hospital, Nankai University, Tianjin, China.
Heliyon. 2024 Oct 17;10(23):e39497. doi: 10.1016/j.heliyon.2024.e39497. eCollection 2024 Dec 15.
To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection affects corneal morphology and optical quality.
In this cross-sectional study, ophthalmological indicators were examined during the peak of SARS-CoV-2 infection after adjusting for public health control measures. Participants were divided into control (remained uninfected), A (infected during follow-up), and B (infected prior to the first consultation) groups. Effects of varying SARS-CoV-2 infection levels were determined using reverse transcription polymerase chain reaction. Changes in corneal morphology, backscatter, and aberrations were measured. Corneal parameters, such as flat keratometry, steep keratometry, and surface variance, vertical asymmetry, height asymmetry, and height decentration indices were considered.
Overall, 110 participants (208 eyes, 42.7 % male; age 17-31 years) were enrolled. Eighteen (16.3 %) were infection-free during the outbreak with unchanged corneal morphology, backscatter, and aberration. In group A, 34.73 ± 9.30 days after infection, the backscatter of the anterior corneal layer and central layer (both p = 0.000) decreased. Total low-order aberration, defocus, horizontal coma, and spherical aberration of the cornea increased (p < 0.05), while corneal morphology after infection did not change (p > 0.05). In group B, a decrease in backscattering in the corneal middle layer and an increase in horizontal coma (p < 0.05) were noted.
Backscattering of the anterior and intermediate layers of the cornea decreased and corneal aberrations increased after SARS-CoV-2 infection, which affected corneal optical quality. However, corneal morphology and thickness remained unchanged. Ophthalmological indicators and optical quality should be monitored during SARS-CoV-2 infection.
确定严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染是否会影响角膜形态和光学质量。
在这项横断面研究中，在调整公共卫生控制措施后，于SARS-CoV-2感染高峰期检查眼科指标。参与者被分为对照组（未感染）、A组（随访期间感染）和B组（首次就诊前感染）。使用逆转录聚合酶链反应确定不同SARS-CoV-2感染水平的影响。测量角膜形态、后向散射和像差的变化。考虑角膜参数，如平角膜曲率、陡角膜曲率、表面方差、垂直不对称性、高度不对称性和高度偏心指数。
总体而言，共纳入110名参与者（208只眼，男性占42.7%；年龄17 - 31岁）。18名（16.3%）在疫情期间未感染，角膜形态、后向散射和像差未发生变化。在A组中，感染后34.73±9.30天，角膜前层和中央层的后向散射降低（p均=0.000）。角膜的总低阶像差、散焦、水平彗差和球差增加（p<0.05），而感染后角膜形态未改变（p>0.05）。在B组中，角膜中层的后向散射降低，水平彗差增加（p<0.05）。
SARS-CoV-2感染后，角膜前层和中间层的后向散射降低，角膜像差增加，这影响了角膜光学质量。然而，角膜形态和厚度保持不变。在SARS-CoV-2感染期间应监测眼科指标和光学质量。
