Catoe Jack, Siref Andrew, Huerter Christopher
Dermatology, Creighton University School of Medicine, Omaha, USA.
Pathology, Creighton University School of Medicine, Omaha, USA.
Cureus. 2024 Nov 15;16(11):e73762. doi: 10.7759/cureus.73762. eCollection 2024 Nov.
Hypertrophic lichen planus (HLP) is an idiopathic inflammatory condition characterized by hyperkeratotic plaques or nodules, typically occurring bilaterally on the wrists, ankles, or lower extremities. This variant of lichen planus is more common among African-American patients and occupies a broad differential with other keratotic skin conditions, some of which are malignant, making recognition and accurate diagnosis essential. We present an unusual case of a 49-year-old African-American woman with four markedly exophytic, horn-like lesions on her shins, ultimately diagnosed as HLP. Her medical history was also notable for ichthyosis vulgaris. Although no known interaction exists between HLP and ichthyosis vulgaris, the combination of these conditions may have contributed to intense pruritus, leading to increased excoriation. This excoriation could have influenced the unusual growth pattern, as mechanical disruption is associated with increased keratin production in hyperkeratotic conditions.
肥厚性扁平苔藓(HLP)是一种特发性炎症性疾病,其特征为角化过度的斑块或结节,通常双侧发生于手腕、脚踝或下肢。这种扁平苔藓变体在非裔美国患者中更为常见,与其他角化性皮肤病存在广泛的鉴别诊断,其中一些是恶性的,因此识别和准确诊断至关重要。我们报告了一例不寻常的病例,一名49岁的非裔美国女性,其小腿上有四个明显外生性的角状病变,最终被诊断为HLP。她的病史中寻常型鱼鳞病也很显著。虽然HLP和寻常型鱼鳞病之间不存在已知的相互作用,但这两种疾病的组合可能导致了剧烈瘙痒,进而导致抓挠增加。这种抓挠可能影响了异常的生长模式,因为在角化过度的情况下,机械性破坏与角蛋白生成增加有关。