磷化铟纳米激光粒子的宽带调谐与深层组织光谱检测

Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles.

作者信息

Cho Sangyeon, Moon Wonjoon, Martino Nicola, Yun Seok Hyun

机构信息

Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Cambridge, Massachusetts, 02139, USA.

Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

出版信息

bioRxiv. 2024 Dec 3:2024.11.29.626128. doi: 10.1101/2024.11.29.626128.

DOI:10.1101/2024.11.29.626128

PMID:39677764

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642806/

Abstract

Laser particles (LPs) emitting narrowband spectra across wide spectral ranges are highly promising for high-multiplex optical barcoding. Here, we present LPs based on indium phosphide (InP) nanodisks, operating in the near-infrared wavelength range of 740-970 nm. Utilizing low-order whispering gallery resonance modes in size-tuned nanodisks, we achieved an ultrawide color palette with 27% bandwidth utilization and nanometer-scale linewidth. The minimum laser size was 430 nm in air and 560 nm within the cytoplasm, operating at mode order 4 or 5. We further demonstrated spectral detection of laser peaks with high signal-to-background ratios in highly-scattering media, including 1-cm-thick chicken breast tissue and blood vessels in live mice.

摘要

能在宽光谱范围内发射窄带光谱的激光粒子（LPs）在高复用光学条形码方面极具前景。在此，我们展示了基于磷化铟（InP）纳米盘的激光粒子，其在740 - 970 nm的近红外波长范围内工作。通过利用尺寸调谐纳米盘中的低阶回音壁共振模式，我们实现了具有27%带宽利用率和纳米级线宽的超宽调色板。在空气中，最小激光尺寸为430 nm，在细胞质内为560 nm，以模式阶数4或5运行。我们进一步展示了在高散射介质中对激光峰的光谱检测，这些介质包括1厘米厚的鸡胸组织和活体小鼠的血管，且具有高信噪比。