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用于标准三肢体导联心电图套装的具有3D多通道结构的皮肤电极的自模板制造。

Self-template manufacturing of on-skin electrodes with 3D multi-channel structure for standard 3-limb-lead ECG suit.

作者信息

Wang Wentao, Lu Longsheng, Ma Huan, Li Zehong, Lu Xiaoyu, Xie Yingxi

机构信息

School of Automotive and Mechanical Engineering, Changsha University of Science and Technology, Changsha, 410114, China.

Guangdong Key Laboratory of Precision Equipment and Manufacturing Technology, South China University of Technology, Guangzhou, 510641, China.

出版信息

Microsyst Nanoeng. 2024 Dec 16;10(1):196. doi: 10.1038/s41378-024-00838-7.

Abstract

Wearable electrocardiogram (ECG) devices are the mainstream technology in the diagnosis of various cardiovascular diseases, in which soft, flexible, permeable electrodes are the key link in human-machine interface to capture bioelectrical signals. Herein, we propose a self-template strategy to fabricate silver-coated fiber/silicone (AgCF-S) electrodes. With a simple dissolving-curing-redissolving process, the polyvinyl acetate shell around the AgCF core is in-situ removed to form a three-dimensional (3D) multi-channel structure. The conductive fibers overlap each other and pass through the silicon substrate in a network state, so that the electrode can be bent to 180° or stretched to 30%. The 3D multi-channels in AgCF-S adhesive is further coupled with a Kirigami-design structure of flexible substrate, to maintain high flexibility without sacrificing air-permeability, enabling an excellent water evaporation rate of 1.8 μg/mm/min, and non-allergenic adhere on pigskin after 24 h. Combined with the self-developed standard 3-limb-lead ECG suit, multi-lead signals with high signal-to-noise ratio (SNR) and low variance (σ), can be transmitted in real-time via Bluetooth and displayed in the client. Typical heart diseases such as coronary, arrhythmia, myocardial infarction, etc., are detected by our ECG equipment, revealing a huge promise in future medical electronics.

摘要

可穿戴心电图(ECG)设备是诊断各种心血管疾病的主流技术,其中柔软、灵活、透气的电极是人机界面中捕获生物电信号的关键环节。在此,我们提出一种自模板策略来制备银包覆纤维/硅酮(AgCF-S)电极。通过简单的溶解-固化-再溶解过程,原位去除AgCF核周围的聚醋酸乙烯酯壳,形成三维(3D)多通道结构。导电纤维相互重叠并以网络状态穿过硅基板,使电极能够弯曲至180°或拉伸至30%。AgCF-S粘合剂中的3D多通道进一步与柔性基板的折纸设计结构相结合,在不牺牲透气性的情况下保持高柔韧性,实现1.8μg/mm/min的优异水分蒸发速率,并在24小时后能在猪皮上实现无过敏粘附。结合自行研发的标准三导联心电图套装,具有高信噪比(SNR)和低方差(σ)的多导联信号可通过蓝牙实时传输并显示在客户端。我们的心电图设备能够检测出诸如冠心病、心律失常、心肌梗死等典型心脏病,在未来医疗电子领域展现出巨大的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75bd/11649698/179a6d76def4/41378_2024_838_Fig1_HTML.jpg

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