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富含不饱和脂肪酸的乳制品在脂肪细胞代谢中的作用

The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism.

作者信息

Machado Manuela, Costa Eduardo M, Silva Sara, Gomes Ana Maria, Pintado Manuela

机构信息

Universidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.

出版信息

Molecules. 2024 Nov 21;29(23):5502. doi: 10.3390/molecules29235502.

DOI:10.3390/molecules29235502
PMID:39683663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643689/
Abstract

This study investigated the fatty acid profile, permeability, and metabolic effects of a functional yogurt enriched with pomegranate oil, focusing on its impact on lipid metabolism and inflammatory responses. The yogurt's fatty acid composition was primarily composed of long-chain polyunsaturated fatty acids (54.37%), followed by saturated (29.34%) and monounsaturated fatty acids (16.36%). During in vitro digestion, a shift in fatty acid profile was observed, with a decrease in polyunsaturated and saturated fatty acids and a slight increase in monounsaturated fatty acids due to hydrolysis. This study further analyzed fatty acid permeability across Caco-2/HT29-MTX monolayers and 3T3-L1 cell uptake, revealing higher permeability for saturated fatty acids than unsaturated ones. In 3T3-L1 cells, permeated fatty acids induced higher lipolysis and increased adiponectin secretion without affecting leptin levels. Cytokine analysis indicated a decrease in pro-inflammatory markers, such as MCP-1, and a significant increase in anti-inflammatory cytokines like IL-10, suggesting potential benefits in reducing obesity-related inflammation. These results underscore the role of functional yogurts enriched with polyunsaturated fatty acids as promising agents for modulating lipid metabolism and inflammatory responses.

摘要

本研究调查了富含石榴籽油的功能性酸奶的脂肪酸谱、渗透性和代谢效应，重点关注其对脂质代谢和炎症反应的影响。该酸奶的脂肪酸组成主要由长链多不饱和脂肪酸（54.37%）组成，其次是饱和脂肪酸（29.34%）和单不饱和脂肪酸（16.36%）。在体外消化过程中，观察到脂肪酸谱发生了变化，由于水解作用，多不饱和脂肪酸和饱和脂肪酸减少，单不饱和脂肪酸略有增加。本研究进一步分析了脂肪酸跨Caco-2/HT29-MTX单层的渗透性以及3T3-L1细胞的摄取情况，结果显示饱和脂肪酸的渗透性高于不饱和脂肪酸。在3T3-L1细胞中，渗透的脂肪酸诱导了更高的脂肪分解，并增加了脂联素的分泌，而不影响瘦素水平。细胞因子分析表明，促炎标志物如MCP-1减少，抗炎细胞因子如IL-10显著增加，这表明在减轻肥胖相关炎症方面具有潜在益处。这些结果强调了富含多不饱和脂肪酸的功能性酸奶作为调节脂质代谢和炎症反应的有前景的药物的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/8d15a9478153/molecules-29-05502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/c95018f57db2/molecules-29-05502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/5cfb1425b0b4/molecules-29-05502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/4f25a0cc4e95/molecules-29-05502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/8d15a9478153/molecules-29-05502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/c95018f57db2/molecules-29-05502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/5cfb1425b0b4/molecules-29-05502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/4f25a0cc4e95/molecules-29-05502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d28/11643689/8d15a9478153/molecules-29-05502-g004.jpg

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本文引用的文献

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Anti-obesity potential of a yogurt functionalized with a CLNA-rich pomegranate oil.富含共轭亚油酸的石榴籽油功能化酸奶的抗肥胖潜力
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Fatty Acids and their Proteins in Adipose Tissue Inflammation.
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