Shahina Zinnat, Dahms Tanya E S
Department of Chemistry and Biochemistry, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada.
Molecules. 2024 Nov 23;29(23):5536. doi: 10.3390/molecules29235536.
is an emerging multidrug-resistant opportunistic pathogen that causes candidiasis, superficial infections on the mucosa, nails or skin, and life-threatening candidemia in deep tissue when disseminated through the bloodstream. Recently, there has been a sharp rise in resistant strains, posing a considerable clinical challenge for the treatment of candidiasis. There has been a resurged interest in the pharmacological properties of essential oils and their active components, for example, monoterpenes with alcohol (-OH) and aldehyde (-CHO) groups. Eugenol and citral have shown promising in vitro and in vivo activity against species. Although there is substantial research on the efficacy of these essential oil components against , a detailed knowledge of their mycological mechanisms is lacking. To explore the broad-spectrum effects of EOs, it is more meaningful and rational to study the whole essential oil, along with some of its major components. This review provides a comprehensive overview of eugenol and citral anticandidal and antivirulence activity, alone and together, along with the associated mechanisms and limitations of our current knowledge.
是一种新兴的多重耐药机会性病原体，可引起念珠菌病、黏膜、指甲或皮肤的浅表感染，以及通过血流播散至深部组织时危及生命的念珠菌血症。最近，耐药菌株急剧增加，给念珠菌病的治疗带来了相当大的临床挑战。人们对精油及其活性成分的药理特性重新产生了兴趣，例如带有醇基（-OH）和醛基（-CHO）的单萜类化合物。丁香酚和柠檬醛已显示出对该菌种有前景的体外和体内活性。尽管对这些精油成分抗该菌的功效有大量研究，但缺乏对其真菌学机制的详细了解。为了探索精油的广谱作用，研究整个精油及其一些主要成分更有意义且合理。本综述全面概述了丁香酚和柠檬醛单独及联合的抗念珠菌和抗毒力活性，以及相关机制和我们当前知识的局限性。
