Stewart S, Fawcett J, Jacobson W
J Pathol. 1985 Jan;145(1):53-8. doi: 10.1002/path.1711450105.
The occurrence of multiple intrathoracic petechial haemorrhages in sudden infant death syndrome is well-documented and undisputed. We describe a study of 24 consecutive sudden infant deaths in which Perls' method for staining of iron in lung sections has been employed in addition to standard post-mortem procedures. Haemosiderin-containing macrophages have been demonstrated in 13 infants in subpleural and interstitial lung tissue in the absence of local fresh interstitial haemorrhage; ten of these infants had no evidence of respiratory tract inflammation and died mainly between one and three months of age. Eleven babies without haemosiderin showed evidence of inflammatory lesions and were predominantly four months or older at death. The demonstration of previous haemorrhagic foci in babies showing no other pathological abnormality may represent a histological hallmark of previous 'near-miss' episodes of hypoxaemia from whatever cause.
婴儿猝死综合征中出现多处胸腔内瘀点性出血已有充分记录且无可争议。我们描述了一项对24例连续婴儿猝死的研究，除了标准的尸检程序外，还采用了Perls法对肺切片中的铁进行染色。在13例婴儿的胸膜下和肺间质组织中发现了含铁血黄素巨噬细胞，而局部无新鲜间质出血；其中10例婴儿无呼吸道炎症证据，主要死于1至3个月龄。11例无含铁血黄素的婴儿有炎症病变证据，死亡时主要为4个月或更大年龄。在无其他病理异常的婴儿中发现先前的出血灶，可能代表了无论何种原因导致的先前低氧血症“接近死亡”发作的组织学特征。
