S Hariharan, K Gayathri, Pl Ravishankar, Blaisie Rajula Prem, Rao Sunanda, Kodali Murali Venkata Rama Mohan, V Kalaivani, A V Saravanan, Esther Viola, Brahma Supriti
Periodontology, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, Chengalpattu, IND.
Oral and Maxillofacial Surgery, King Faisal University, Al Ahsa, SAU.
Cureus. 2024 Nov 15;16(11):e73789. doi: 10.7759/cureus.73789. eCollection 2024 Nov.
Periodontal disease is a major contributing factor to tooth loss and can significantly impact overall health. Traditional periodontal therapy typically involves mechanical debridement to remove plaque and calculus, along with the use of antimicrobial agents to reduce bacterial load. Licorice () has a long history of use in traditional medicine for treating various ailments since it contains glycyrrhizin, glabridin, liquiritin, and flavonoids, which possess anti-inflammatory, antioxidant, and antimicrobial activities. Hence, licorice can be considered a viable alternative for managing periodontal inflammation.
The objective of this study is to conduct a comparative evaluation of the antimicrobial efficacy of ethanolic and aqueous extracts of licorice () against a key periodontal pathogen, Methodology: In this study, aqueous and ethanolic preparation of licorice was done, and the antimicrobial effect of these extracts against was tested by evaluating the minimum inhibitory concentration (MIC). The gold standard chemical plaque control agent chlorhexidine was used as a control. Result: Results of the present study showed that licorice extract has antimicrobial activity against The MIC of aqueous and ethanolic licorice root extracts against was established at 0.8% and 0.1%, respectively. When the aqueous and ethanolic extracts were compared, the ethanolic extract of licorice showed significantly more antimicrobial properties than the aqueous extract.
Ethanolic extract of licorice possesses highly significant antibacterial activity against ; hence, it can be used as an alternative to chlorhexidine mouthwash.
牙周病是导致牙齿脱落的主要因素，会对整体健康产生重大影响。传统的牙周治疗通常包括机械清创以去除牙菌斑和牙结石，以及使用抗菌剂来减少细菌载量。甘草在传统医学中用于治疗各种疾病已有很长历史，因为它含有甘草甜素、光甘草定、甘草苷和黄酮类化合物，具有抗炎、抗氧化和抗菌活性。因此，甘草可被视为控制牙周炎症的一种可行替代方法。
本研究的目的是对甘草的乙醇提取物和水提取物对一种关键牙周病原体的抗菌效果进行比较评估。
在本研究中，制备了甘草的水提取物和乙醇提取物，并通过评估最低抑菌浓度（MIC）来测试这些提取物对该病原体的抗菌效果。使用金标准化学菌斑控制剂氯己定作为对照。
本研究结果表明，甘草提取物对该病原体具有抗菌活性。甘草根水提取物和乙醇提取物对该病原体的MIC分别确定为0.8%和0.1%。当比较水提取物和乙醇提取物时，甘草乙醇提取物显示出比水提取物更强的抗菌性能。
甘草乙醇提取物对该病原体具有高度显著的抗菌活性；因此，它可作为氯己定漱口水的替代品。
