Richters A, Richters V, Alley W P
J Surg Oncol. 1985 Jan;28(1):63-6. doi: 10.1002/jso.2930280115.
A study was carried out to determine the interrelationship between the inhalation of nitrogen dioxide (0.4 +/- 0.50 ppm), lung metastases development from circulating cancer cells, and death rate from such metastases. C57 BL/6J mice were used in these experiments. Animals were divided into control and NO2-exposed groups, and were exposed to filtered air and 0.4 ppm of NO2, respectively. Following 12 weeks of exposure, all animals were infused intravenously with syngeneic, viable B16 melanoma cells. The results indicate that a subpopulation of NO2-exposed animals showed a significant increase in mortality rate during the early part of the experiment. The interpretation is that animals especially sensitive to the NO2 insult developed extensive metastases at an early stage. The question raised is whether or not the progression of human cancer is influenced by the inhalation of noxious pollutants in the ambient atmosphere.
开展了一项研究，以确定吸入二氧化氮（0.4±0.50 ppm）、循环癌细胞导致的肺转移发展以及此类转移导致的死亡率之间的相互关系。这些实验使用了C57 BL/6J小鼠。动物被分为对照组和二氧化氮暴露组，分别暴露于过滤空气和0.4 ppm的二氧化氮中。暴露12周后，所有动物均通过静脉注射同基因的活B16黑色素瘤细胞。结果表明，在实验早期，二氧化氮暴露动物亚群的死亡率显著增加。其解释是，对二氧化氮损伤特别敏感的动物在早期就发生了广泛转移。由此提出的问题是，环境大气中有害污染物的吸入是否会影响人类癌症的进展。
