Richters A, Richters V
Arch Environ Health. 1983 Mar-Apr;38(2):69-75. doi: 10.1080/00039896.1983.10543983.
Many studies have been conducted to investigate the effects of different air pollutants on health. Our studies have focused on the effects of nitrogen dioxide (NO2), and recently we reported that inhalation of low levels of NO2 can facilitate cancer cell metastasis. The study described herein utilized the same B16 mouse melanoma metastasis model of previous investigations, but under different NO2 exposure conditions. The results provide further evidence that inhalation of ambient level NO2 (0.4 ppm) or polluted urban ambient air play a role in facilitation of blood-borne cancer cell metastasis. In addition, results show different patterns of melanoma cell distribution in the lungs of NO2- and ambient-air exposed animals. They also indicate that extended periods of clean air between NO2 exposures may diminish the severity of the insult in the less sensitive animals. It is our conclusion that the results provide strong support for the need of improved air quality and for reduction of noxious pollutants in urban ambient air.
许多研究已开展以调查不同空气污染物对健康的影响。我们的研究聚焦于二氧化氮（NO₂）的影响，最近我们报告称吸入低水平的NO₂可促进癌细胞转移。本文所述的研究采用了与先前调查相同的B16小鼠黑色素瘤转移模型，但处于不同的NO₂暴露条件下。结果提供了进一步的证据，表明吸入环境水平的NO₂（0.4 ppm）或受污染的城市环境空气在促进血源性癌细胞转移中起作用。此外，结果显示在暴露于NO₂和环境空气的动物肺部，黑色素瘤细胞分布模式不同。它们还表明，在NO₂暴露之间延长清洁空气的时间可能会减轻较不敏感动物的损伤严重程度。我们的结论是，这些结果为改善空气质量以及减少城市环境空气中的有害污染物的必要性提供了有力支持。
