Richters A, Kuraitis K
Arch Environ Health. 1981 Jan-Feb;36(1):36-9. doi: 10.1080/00039896.1981.10667604.
An experimental model was designed where the frequency of blood-borne cancer cell metastases to the lungs of animals was used as an indicator to detect adverse effects of inhaled nitrogen dioxide (NO2). Animals were exposed to air containing 0.40 +/- 0.05 ppm or 0.80 +/- 0.05 ppm of NO2. After the appropriate exposure periods, the animals were infused intravenously with B16 mouse melanoma cells. At 3 wk post-infusion the animals were killed and the lungs were examined for melanoma nodule development. The lungs of the NO2-exposed animals contained a significantly higher number of melanoma nodules than the lungs of control animals (P less than .0025). These results indicate that inhalation of ambient or near ambient levels of NO2 influences the metastasis of blood-borne cancer cells. This raises the possibility that similar events may occur in the human population.
设计了一种实验模型，以动物肺部血源性癌细胞转移的频率作为指标，来检测吸入二氧化氮（NO₂）的不良影响。将动物暴露于含有0.40±0.05 ppm或0.80±0.05 ppm NO₂的空气中。在适当的暴露期后，给动物静脉注射B16小鼠黑色素瘤细胞。注射后3周处死动物，检查肺部黑色素瘤结节的形成情况。与对照动物的肺部相比，暴露于NO₂的动物肺部的黑色素瘤结节数量显著更多（P<0.0025）。这些结果表明，吸入环境水平或接近环境水平的NO₂会影响血源性癌细胞的转移。这增加了人类群体中可能发生类似事件的可能性。
