Sanesi Lorenzo, Puca Valentina, Caponio Vito Carlo Alberto, Pinti Morena, Balice Giuseppe, Femminella Beatrice, Paolantonio Michele, Cela Ilaria, Kaushik Nagendra Kumar, Choi Eun Ha, Grande Rossella, Sardella Eloisa, Perrotti Vittoria
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Front Oral Health. 2024 Dec 3;5:1483078. doi: 10.3389/froh.2024.1483078. eCollection 2024.
The intricate structure of the tooth root canals has a role in the colonization and biofilm formation in hidden areas that are hardly reached by standard endodontic treatments. This review aims at summarizing data from and studies for a better understanding of the application of cold atmospheric plasma (CAP) for the disinfection of dental root canals.
PubMed, Scopus, and Web of Science databases were screened. Characteristics of the included studies were extracted, and a meta-analysis on studies was carried out to evaluate the effect of CAP on colony forming unit assay of . The study was performed following the PRISMA 2020 guidelines.
A total of 31 studies fulfilled the selection criteria. Only 2 investigations reported an indirect plasma treatment, 28 trials used direct CAP administration, while 1 study applied both methods. Most of the studies were conducted on using as carrier gas Helium or Argon alone or in combination with Oxygen as well air. A considerable heterogeneity among studies was found regarding treatments which varied for source type, settings, and protocols of application. Despite this, CAP showed effectiveness in reducing colony forming unit with a standardized mean difference of 4.51, 95% C.I. = 2.55-6.48, -value < 0.001.
The data demonstrated the antimicrobial effect of direct CAP application against microorganisms. studies showed an effect that depended on the time and distance of treatment, while the meta-analysis performed on studies showed that the effect of CAP was independent of time and distance.
https://doi.org/10.17605/OSF.IO/BJ59V, identifier OSF registries.
牙根根管的复杂结构在标准根管治疗难以触及的隐蔽区域的细菌定植和生物膜形成中起作用。本综述旨在总结相关研究数据，以更好地理解冷大气等离子体（CAP）在牙根根管消毒中的应用。
对PubMed、Scopus和Web of Science数据库进行筛选。提取纳入研究的特征，并对相关研究进行荟萃分析，以评估CAP对某菌菌落形成单位测定的影响。该研究按照PRISMA 2020指南进行。
共有31项研究符合入选标准。仅2项研究报告了间接等离子体处理，28项试验使用直接CAP给药，1项研究同时应用了这两种方法。大多数研究以某菌为对象，使用氦气或氩气单独或与氧气以及空气混合作为载气。在处理方面发现研究之间存在相当大的异质性，处理在源类型、设置和应用方案方面各不相同。尽管如此，CAP在减少某菌菌落形成单位方面显示出有效性，标准化平均差为4.51，95%置信区间=2.55 - 6.48，P值<0.001。
数据表明直接应用CAP对微生物具有抗菌作用。相关研究表明其效果取决于治疗时间和距离，而对相关研究进行的荟萃分析表明CAP的效果与时间和距离无关。
